ATP-binding cassette (ABC) transporters mediate the ATP-driven translocation of structurally
and mechanistically distinct substrates against steep concentration gradients. Among the …

The transport of specific molecules across lipid membranes is an essential function of all
living organisms. The processes are usually mediated by specific transporters. One of the …

Multidrug resistance (MDR) is a serious phenomenon employed by cancer cells which
hampers the success of cancer pharmacotherapy. One of the common mechanisms of MDR …

Highlights•The most common reason for the failure of the cancer treatment is the evolving
drug resistance.•The ABC transporters mainly P-gp, BCRP and MRP1 are responsible for …

ATP-binding cassette (ABC) transporters represent one of the largest and oldest families of
membrane proteins in all extant phyla from prokaryotes to humans, which couple the energy …

To date, over 100 small-molecule oncology drugs have been approved by the FDA.
Because of the inherent heterogeneity of tumors, these small molecules are often …

The ATP-binding cassette transporter G2 (ABCG2; also known as breast cancer resistance
protein, BCRP) has been suggested to be involved in clinical multidrug resistance (MDR) in …

Multidrug resistance (MDR) triggered by ATP binding cassette (ABC) transporter such as
ABCB1, ABCC1, ABCG2 limited successful cancer chemotherapy. Unfortunately, no …

The synthesis and the evaluation of the efficacy of a cycloruthenated complex, RuZ, is
reported, to overcome multi‐drug resistance (MDR) in cancer cells. RuZ can self‐assemble …

The overexpression of the human ATP-binding cassette (ABC) transporters in cancer cells is
a common mechanism involved in developing multidrug resistance (MDR). Unfortunately …