Recent trends of capillary electrophoresis‐mass spectrometry in proteomics research

FP Gomes, JR Yates III - Mass spectrometry reviews, 2019 - Wiley Online Library
Progress in proteomics research has led to a demand for powerful analytical tools with high
separation efficiency and sensitivity for confident identification and quantification of proteins …

Ion activation methods for peptides and proteins

LA Macias, IC Santos, JS Brodbelt - Analytical chemistry, 2019 - ACS Publications
Mass spectrometry is well-established as one of the primary methods used to characterize
peptides and proteins. New advances in instrumentation and innovative analytical workflows …

Capillary isoelectric focusing-mass spectrometry method for the separation and online characterization of intact monoclonal antibody charge variants

J Dai, J Lamp, Q Xia, Y Zhang - Analytical chemistry, 2018 - ACS Publications
We report a new online capillary isoelectric focusing-mass spectrometry (CIEF-MS) method
for monoclonal antibody (mAb) charge variant analysis using an electrokinetically pumped …

Recent advances in protein analysis by capillary and microchip electrophoresis

M Dawod, NE Arvin, RT Kennedy - Analyst, 2017 - pubs.rsc.org
This review article describes the significant recent advances in the analysis of proteins by
capillary and microchip electrophoresis during the period from mid-2014 to early 2017. This …

Capillary zone electrophoresis-mass spectrometry for top-down proteomics

X Shen, Z Yang, EN McCool, RA Lubeckyj… - TrAC Trends in …, 2019 - Elsevier
Mass spectrometry (MS)-based top-down proteomics characterizes complex proteomes at
the intact proteoform level and provides an accurate picture of protein isoforms and protein …

[HTML][HTML] Carbon footprint of the analytical laboratory and the three-dimensional approach to its reduction

PM Nowak, A Bis, M Rusin, M Woźniakiewicz - Green Analytical Chemistry, 2023 - Elsevier
What is the carbon footprint of a common HPLC instrument per one measurement? How
much will it increase when we use a mass detector instead of a spectrophotometer? What is …

Recent applications of capillary electromigration methods to separation and analysis of proteins

S Štěpánová, V Kašička - Analytica Chimica Acta, 2016 - Elsevier
This review article describes the significant recent developments in analysis of proteins by
capillary electromigration (CE) methods (zone electrophoresis, isotachophoresis, isoelectric …

Insights from capillary electrophoresis approaches for characterization of monoclonal antibodies and antibody drug conjugates in the period 2016–2018

A Lechner, J Giorgetti, R Gahoual, A Beck… - … of Chromatography B, 2019 - Elsevier
Monoclonal antibodies (mAbs) and their related products as antibody-drug-conjugates
(ADCs) or biosimilars represent a constantly growing class of molecules therapeutic proteins …

Recent advances in CE‐MS coupling: Instrumentation, methodology, and applications

A Týčová, V Ledvina, K Klepárník - Electrophoresis, 2017 - Wiley Online Library
This review focuses on the latest development of microseparation electromigration methods
in capillaries and microfluidic devices coupled with MS for detection and identification of …

Cutting-edge capillary electrophoresis characterization of monoclonal antibodies and related products

R Gahoual, A Beck, E Leize-Wagner… - … of Chromatography B, 2016 - Elsevier
Out of all categories, monoclonal antibodies (mAbs), biosimilar, antibody-drug conjugates
(ADCs) and Fc-fusion proteins attract the most interest due to their strong therapeutic …