G protein–coupled receptor interactions with arrestins and GPCR kinases: The unresolved issue of signal bias
Q Chen, JJG Tesmer - Journal of Biological Chemistry, 2022 - ASBMB
G protein–coupled receptor (GPCR) kinases (GRKs) and arrestins interact with agonist-
bound GPCRs to promote receptor desensitization and downregulation. They also trigger …
bound GPCRs to promote receptor desensitization and downregulation. They also trigger …
GPCR activation and GRK2 assembly by a biased intracellular agonist
J Duan, H Liu, F Zhao, Q Yuan, Y Ji, X Cai, X He, X Li… - Nature, 2023 - nature.com
Phosphorylation of G-protein-coupled receptors (GPCRs) by GPCR kinases (GRKs)
desensitizes G-protein signalling and promotes arrestin signalling, which is also modulated …
desensitizes G-protein signalling and promotes arrestin signalling, which is also modulated …
Differential regulation of GPCRs—are GRK expression levels the key?
ESF Matthees, RS Haider, C Hoffmann… - Frontiers in Cell and …, 2021 - frontiersin.org
G protein-coupled receptors (GPCRs) comprise the largest family of transmembrane
receptors and their signal transduction is tightly regulated by GPCR kinases (GRKs) and β …
receptors and their signal transduction is tightly regulated by GPCR kinases (GRKs) and β …
GPCR kinase knockout cells reveal the impact of individual GRKs on arrestin binding and GPCR regulation
G protein-coupled receptors (GPCRs) activate G proteins and undergo a complex regulation
by interaction with GPCR kinases (GRKs) and the formation of receptor–arrestin complexes …
by interaction with GPCR kinases (GRKs) and the formation of receptor–arrestin complexes …
Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1
G-protein-coupled receptor (GPCR) kinases (GRKs) selectively phosphorylate activated
GPCRs, thereby priming them for desensitization. Although it is unclear how GRKs …
GPCRs, thereby priming them for desensitization. Although it is unclear how GRKs …
G protein coupled pattern recognition receptors expressed in neutrophils: recognition, activation/modulation, signaling and receptor regulated functions
C Dahlgren, S Lind, J Mårtensson… - Immunological …, 2023 - Wiley Online Library
Neutrophils, the most abundant white blood cell in human blood, express receptors that
recognize damage/microbial associated pattern molecules of importance for cell recruitment …
recognize damage/microbial associated pattern molecules of importance for cell recruitment …
Signaling by neutrophil G protein-coupled receptors that regulate the release of superoxide anions
C Dahlgren, H Forsman, M Sundqvist… - Journal of Leukocyte …, 2024 - academic.oup.com
In human peripheral blood, the neutrophil granulocytes (neutrophils) are the most abundant
white blood cells. These professional phagocytes are rapidly recruited from the bloodstream …
white blood cells. These professional phagocytes are rapidly recruited from the bloodstream …
GRK2 in cardiovascular disease and its potential as a therapeutic target
KM Ferrero, WJ Koch - Journal of Molecular and Cellular Cardiology, 2022 - Elsevier
Cardiovascular diseases (CVDs) represent the leading cause of death globally. Despite
major advances in the field of pharmacological CVD treatments, particularly in the field of …
major advances in the field of pharmacological CVD treatments, particularly in the field of …
Generation of Comprehensive GPCR-Transducer-Deficient Cell Lines to Dissect the Complexity of GPCR Signaling
G-protein–coupled receptors (GPCRs) compose the largest family of transmembrane
receptors and are targets of approximately one-third of Food and Drug Administration …
receptors and are targets of approximately one-third of Food and Drug Administration …
Analysis of CCR2 splice variant expression patterns and functional properties
Background C–C motif chemokine receptor 2 (CCR2), the main receptor for monocyte
chemoattractant protein-1 (MCP-1), is expressed on immune cells, including monocytes …
chemoattractant protein-1 (MCP-1), is expressed on immune cells, including monocytes …