Making sense of the ageing methylome
Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …
been associated with a broad range of age-related diseases, including cardiovascular …
Early life adversities and lifelong health outcomes: A review of the literature on large, social, long-lived nonhuman mammals
AM Dettmer, DE Chusyd - Neuroscience & Biobehavioral Reviews, 2023 - Elsevier
Social nonhuman animals are powerful models for studying underlying factors related to
lifelong health outcomes following early life adversities (ELAs). ELAs can be linked to …
lifelong health outcomes following early life adversities (ELAs). ELAs can be linked to …
A mammalian methylation array for profiling methylation levels at conserved sequences
A Arneson, A Haghani, MJ Thompson… - Nature …, 2022 - nature.com
Infinium methylation arrays are not available for the vast majority of non-human mammals.
Moreover, even if species-specific arrays were available, probe differences between them …
Moreover, even if species-specific arrays were available, probe differences between them …
Universal DNA methylation age across mammalian tissues
Aging, often considered a result of random cellular damage, can be accurately estimated
using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we …
using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we …
Universal DNA methylation age across mammalian tissues
Aging is often perceived as a degenerative process resulting from random accrual of cellular
damage over time. Despite this, age can be accurately estimated by epigenetic clocks based …
damage over time. Despite this, age can be accurately estimated by epigenetic clocks based …
Sex‐specific aging in animals: perspective and future directions
Sex differences in aging occur in many animal species, and they include sex differences in
lifespan, in the onset and progression of age‐associated decline, and in physiological and …
lifespan, in the onset and progression of age‐associated decline, and in physiological and …
Biological clocks as age estimation markers in animals: a systematic review and meta‐analysis
LS Le Clercq, A Kotzé, JP Grobler… - Biological …, 2023 - Wiley Online Library
Various biological attributes associated with individual fitness in animals change predictably
over the lifespan of an organism. Therefore, the study of animal ecology and the work of …
over the lifespan of an organism. Therefore, the study of animal ecology and the work of …
DNA methylation aging and transcriptomic studies in horses
Cytosine methylation patterns have not yet been thoroughly studied in horses. Here, we
profile n= 333 samples from 42 horse tissue types at loci that are highly conserved between …
profile n= 333 samples from 42 horse tissue types at loci that are highly conserved between …
Comparative epigenome analysis using Infinium DNA methylation BeadChips
The arrival of the Infinium DNA methylation BeadChips for mice and other nonhuman
mammalian species has outpaced the development of the informatics that supports their use …
mammalian species has outpaced the development of the informatics that supports their use …
Epigenetic models developed for plains zebras predict age in domestic horses and endangered equids
Effective conservation and management of threatened wildlife populations require an
accurate assessment of age structure to estimate demographic trends and population …
accurate assessment of age structure to estimate demographic trends and population …