Parasitic diseases cause significant global morbidity and mortality, particularly in
underdeveloped regions of the world. Malaria alone causes∼ 800 000 deaths each year …

Histone modifying enzymes have vital roles in the growth and survival of both parasites and
humans. Targeting the epigenome can be a new strategy for the treatment of parasitic …

Plasmodium and Toxoplasma are parasites of major medical importance that belong to the
Apicomplexa phylum of protozoa. These parasites transform into various stages during their …

Malaria, schistosomiasis and leishmaniases are among the most prevalent tropical parasitic
diseases and each requires new innovative treatments. Targeting essential parasite …

The epigenome of the malaria parasite, Plasmodium falciparum, is associated with
regulation of various essential processes in the parasite including control of proliferation …

Epigenetic factors such as histone methylation control the developmental progression of
malaria parasites during the complex life cycle in the human host. We investigated …

Current therapies for human parasite infections rely on a few drugs, most of which have
severe side effects, and their helpfulness is being seriously compromised by the drug …

Histone deacetylase (HDAC) enzymes work together with histone acetyltransferases (HATs)
to reversibly acetylate both histone and non-histone proteins. As a result, these enzymes are …

Despite the recent reductions in the global burden of malaria, this disease remains a
devastating cause of death in tropical and subtropical regions. As there is no broadly …

Synthesis and biological evaluation of the first pentafluorosulfanyl analogs of mefloquine -
Organic & Biomolecular Chemistry (RSC Publishing) DOI:10.1039/B911483A Royal Society …