The past decade has witnessed ongoing progress in precision medicine to improve human
health. As an emerging diagnostic technique, liquid biopsy can provide real-time …

Aptamers are short oligonucleotides isolated in vitro from randomized libraries that can bind
to specific molecules with high affinity, and offer a number of advantages relative to …

Long non-coding RNAs (lncRNAs) are associated to a plethora of cellular functions, most of
which require the interaction with one or more RNA-binding proteins (RBPs); similarly, RBPs …

Coined three decades ago, the term aptamer and directed evolution have now reached their
maturity. The concept that nucleic acid could modulate the activity of target protein as ligand …

Systematic evolution of ligands by exponential enrichment (SELEX) is a well-established
and efficient technology for the generation of oligonucleotides with a high target affinity …

Nucleic acid aptamers are generated by an in vitro molecular evolution method known as
systematic evolution of ligands by exponential enrichment (SELEX). Various candidates are …

Nucleic acid aptamers are promising alternatives to antibodies in analytics. They are
generally obtained through an iterative SELEX protocol that enriches a population of …

Aptamers are single-stranded DNA or RNA oligonucleotides that can selectively bind to a
specific target. They are generally obtained by SELEX, but the procedure is challenging and …

High-throughput sequence (HTS) analysis of combinatorial selection populations
accelerates lead discovery and optimization and offers dynamic insight into selection …

The systematic evolution of ligands by exponential enrichment (SELEX) process enables the
isolation of aptamers from random oligonucleotide libraries. However, it is generally difficult …