[HTML][HTML] The coagulation system in host defense
S Antoniak - Research and Practice in Thrombosis and …, 2018 - Elsevier
The blood coagulation system and immune system of higher organisms are thought to have
a common ancestral origin. During infections, the blood coagulation system is activated and …
a common ancestral origin. During infections, the blood coagulation system is activated and …
An update on factor XI structure and function
Factor XI (FXI) is the zymogen of a plasma protease, factor XIa (FXIa), that contributes to
thrombin generation during blood coagulation by proteolytic activation of several …
thrombin generation during blood coagulation by proteolytic activation of several …
Liver-heart cross-talk mediated by coagulation factor XI protects against heart failure
Tissue-tissue communication by endocrine factors is a vital mechanism for physiologic
homeostasis. A systems genetics analysis of transcriptomic and functional data from a cohort …
homeostasis. A systems genetics analysis of transcriptomic and functional data from a cohort …
Factor XII and uPAR upregulate neutrophil functions to influence wound healing
EX Stavrou, C Fang, KL Bane, AT Long… - The Journal of …, 2018 - Am Soc Clin Investig
Coagulation factor XII (FXII) deficiency is associated with decreased neutrophil migration,
but the mechanisms remain uncharacterized. Here, we examine how FXII contributes to the …
but the mechanisms remain uncharacterized. Here, we examine how FXII contributes to the …
Why factor XI deficiency is a clinical concern
AP Wheeler, D Gailani - Expert review of hematology, 2016 - Taylor & Francis
Introduction: Inherited fXI deficiency has been an enigma since its discovery in 1953. The
variable and relatively mild symptoms in patients with even the most severe form of the …
variable and relatively mild symptoms in patients with even the most severe form of the …
Factor XI as a therapeutic target
Factor XIa is a plasma serine protease that contributes to thrombin generation primarily
through proteolytic activation of factor IX. Traditionally considered part of the intrinsic …
through proteolytic activation of factor IX. Traditionally considered part of the intrinsic …
Targeting factor XI and factor XIa to prevent thrombosis
Direct oral anticoagulants (DOACs) that inhibit the coagulation proteases thrombin or factor
Xa (FXa) have replaced warfarin and other vitamin K antagonists (VKAs) for most indications …
Xa (FXa) have replaced warfarin and other vitamin K antagonists (VKAs) for most indications …
Association of FXI activity with thrombo-inflammation, extracellular matrix, lipid metabolism and apoptosis in venous thrombosis
A Pallares Robles, V Ten Cate, A Schulz… - Scientific reports, 2022 - nature.com
Animal experiments and early phase human trials suggest that inhibition of factor XIa (FXIa)
safely prevents venous thromboembolism (VTE), and specific murine models of sepsis have …
safely prevents venous thromboembolism (VTE), and specific murine models of sepsis have …
[HTML][HTML] Pharmacological targeting of coagulation factor XI mitigates the development of experimental atherosclerosis in low‐density lipoprotein receptor‐deficient …
Background Human coagulation factor (F) XI deficiency, a defect of the contact activation
system, protects against venous thrombosis, stroke, and heart attack, whereas FXII, plasma …
system, protects against venous thrombosis, stroke, and heart attack, whereas FXII, plasma …
Biology of factor XI
Unique among coagulation factors, the coagulation factor XI (FXI) arose through a
duplication of the gene KLKB1, which encodes plasma prekallikrein. This evolutionary origin …
duplication of the gene KLKB1, which encodes plasma prekallikrein. This evolutionary origin …