As the home of cellular genetic information, the nucleus has a critical role in determining cell
fate and function in response to various signals and stimuli. In addition to biochemical …

The term 'fibroblast'often serves as a catch-all for a diverse array of mesenchymal cells,
including perivascular cells, stromal progenitor cells and bona fide fibroblasts. Although …

Metastasis causes most cancer-related deaths; however, the efficacy of anti-metastatic drugs
is limited by incomplete understanding of the biological mechanisms that drive metastasis …

Fibrotic disease is caused by the continuous deposition of extracellular matrix by persistently
activated fibroblasts (also known as myofibroblasts), even after the resolution of the injury …

In breast cancer, the increased stiffness of the extracellular matrix is a key driver of
malignancy. Yet little is known about the epigenomic changes that underlie the tumorigenic …

Cells organize membrane-less internal compartments through a process called liquid–liquid
phase separation (LLPS) to create chemically distinct compartments, referred to as …

Tissue injury disrupts the mechanical homeostasis that underlies normal tissue architecture
and function. The failure to resolve injury and restore homeostasis gives rise to progressive …

Cellular behavior is continuously affected by microenvironmental forces through the process
of mechanotransduction, in which mechanical stimuli are rapidly converted to biochemical …

Abstract Changes in the micro-environment of fibrous connective tissue can lead to
alterations in the phenotypes of tissue-resident cells, yet the underlying mechanisms are …

Bone marrow derived human mesenchymal stem cells (hMSCs) are a promising cell source
for regenerative therapies; however, ex vivo expansion is often required to achieve clinically …