There is great need for stand-alone luminescence-based chemosensors that exemplify
selectivity, sensitivity, and applicability and that overcome the challenges that arise from …

Highlights•We provide an overview of protein-peptide docking methods and their
applications.•Peptide docking tools can be divided on template-based, local and global …

Tissue repair is a very complex event and involves a continuously orchestrated sequence of
signals and responses from platelets, fibroblasts, epithelial, endothelial and immune cells …

Protein–protein interactions (PPIs) are tremendously important for the function of many
biological processes. However, because of the structure of many protein–protein interfaces …

To penetrate solid tumors, low molecular weight (Mw< 10 KDa) compounds have an edge
over antibodies: their higher penetration because of their small size. Because of the dense …

In-solution affinity selection (AS) of large synthetic peptide libraries affords identification of
binders to protein targets through access to an expanded chemical space. Standard affinity …

Pseudomonas are a common cause of hospital-acquired infections that may be lethal. ADP-
ribosyltransferase activities of Pseudomonas exotoxin-S and-T depend on 14-3-3 proteins …

We evaluated a workflow to reliably sample the conformational space of a set of 47 peptidic
macrocycles. Starting from SMILES strings, we use accelerated molecular dynamics …

Cyclized peptides have seen a rise in popularity in the pharmaceutical industry as drug
molecules. As such, new macrocyclization methodologies have become abundant in the last …

Protein complex formation depends on the interplay between preorganization and flexibility
of the binding epitopes involved. The design of epitope mimetics typically focuses on …