The question of addiction specifically concerns (1), the process by which drug‐taking
behavior, in certain individuals, evolves into compulsive patterns of drug‐seeking and drug …

Rationale and objectives: Repeated exposure to many drugs of abuse results in a
progressive and enduring enhancement in the motor stimulant effect elicited by a …

The purpose of the present experiment was to investigate the involvement of NMDA and
AMPA/KA receptors in the nucleus accumbens core and shell in the control over cocaine …

Knowledge of the neural mechanisms underlying the development of benzodiazepine (BZ)
dependence remains incomplete. The γ-aminobutyric acid (GABAA) receptor, being the …

Neuroanatomical and pharmacological evidence implicates glutamate transmission in drug-
environment conditioning that partly controls drug seeking and relapse. Glutamate receptors …

Glutamatergic neurotransmission has been suggested to modulate cue-induced drug-
seeking behavior. Here we examined the effects of metabotropic glutamate receptor …

It has been postulated, consistent with the ubiquitous presence of glutamatergic neurons in
the brain, that defects in glutamatergic neurotransmission are associated with many human …

We previously created a transgenic mouse model of comorbid Tourette's syndrome and
obsessive–compulsive disorder (TS+ OCD), by expressing a neuropotentiating cholera toxin …

The clinical manifestations of drug addiction are the subject of medical literature and fiction
alike. In Novel with Cocaine, first published almost 80 years ago under a pseudonym and …

Activation of group II metabotropic glutamate (mGlu2/3) receptors reduces excessive
glutamate release that is often associated with neurodegenerative and psychiatric disorders …