Cirrhosis–the common end-stage of chronic liver disease–is associated with a cascade of
events, of which intestinal bacterial overgrowth and dysbiosis are central. Bacterial toxins …

Cirrhosis is characterized by inflammation, degeneration, and fibrosis of liver tissue. Along
with being the most common cause of liver failure and liver transplant, cirrhosis is a …

Chronic liver disease is a major cause of morbidity and mortality worldwide. Epidemiology,
clinical phenotype and response to therapies for gastrointestinal and liver diseases are …

Objective The purpose of this study was to describe the changes in the gut microbiome of
patients with cirrhosis and hepatic encephalopathy (HE), as well as quantify the variations in …

There is a complex interplay between the gut microbes, liver, and central nervous system, a
gut-liver-brain axis, where the brain impacts intestinal and hepatic function while the gut and …

Hepatic encephalopathy (HE) is a debilitating neurological complication of chronic liver
disease (CLD). Hyperammonemia plays an important role in HE's pathogenesis, acting …

Methods: In this double-blind trial, patients with OHE admitted to ICU were randomized to
receive antibiotics (ab) alone or antibiotics with rifaximin (ab+ r). Resolution (or 2 grade …

Background There is growing evidence for a relationship between gut microbiota and
hepatic encephalopathy (HE). However, the causal nature of the relationship between gut …

In this systematic and comprehensive overview, we aimed to evaluate the impact of proton
pump inhibitors (PPIs) on chronic liver diseases, especially on cirrhosis. A manual and …

The accumulation of extracellular matrix proteins is the hallmark of liver fibrosis associated
with all chronic liver disease (CLD) types. Liver fibrosis results from repeated bouts of liver …