Metalloproteinases and their inhibitors: potential for the development of new therapeutics
M Raeeszadeh-Sarmazdeh, LD Do, BG Hritz - Cells, 2020 - mdpi.com
The metalloproteinase (MP) family of zinc-dependent proteases, including matrix
metalloproteinases (MMPs), a disintegrin and metalloproteases (ADAMs), and a disintegrin …
metalloproteinases (MMPs), a disintegrin and metalloproteases (ADAMs), and a disintegrin …
Therapeutic potential of matrix metalloproteinase inhibition in breast cancer
ES Radisky… - Journal of cellular …, 2017 - Wiley Online Library
Matrix metalloproteinases (MMPs) are a family of zinc endopeptidases that cleave nearly all
components of the extracellular matrix as well as many other soluble and cell‐associated …
components of the extracellular matrix as well as many other soluble and cell‐associated …
[HTML][HTML] Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer
Matrix metalloproteinases (MMPs) have been implicated in diverse roles in breast cancer
development and progression. While many of the different MMPs expressed in breast cancer …
development and progression. While many of the different MMPs expressed in breast cancer …
[HTML][HTML] Matrix metalloproteinases as breast cancer drivers and therapeutic targets
ES Radisky, DC Radisky - Frontiers in bioscience (Landmark …, 2015 - ncbi.nlm.nih.gov
Members of the matrix metalloproteinase (MMP) family have been identified as poor
prognosis markers for breast cancer patients and as drivers of many facets of the tumor …
prognosis markers for breast cancer patients and as drivers of many facets of the tumor …
Engineering of tissue inhibitor of metalloproteinases TIMP-1 for fine discrimination between closely related stromelysins MMP-3 and MMP-10
M Raeeszadeh-Sarmazdeh, M Coban… - Journal of Biological …, 2022 - ASBMB
Matrix metalloproteinases (MMPs) have long been known as key drivers in the development
and progression of diseases, including cancer and neurodegenerative, cardiovascular, and …
and progression of diseases, including cancer and neurodegenerative, cardiovascular, and …
Directed evolution of the metalloproteinase inhibitor TIMP-1 reveals that its N-and C-terminal domains cooperate in matrix metalloproteinase recognition
M Raeeszadeh-Sarmazdeh, KA Greene… - Journal of Biological …, 2019 - ASBMB
Tissue inhibitors of metalloproteinases (TIMPs) are natural inhibitors of matrix
metalloproteinases (MMPs), enzymes that contribute to cancer and many inflammatory and …
metalloproteinases (MMPs), enzymes that contribute to cancer and many inflammatory and …
Structure and computation-guided yeast surface display for the evolution of TIMP-based matrix metalloproteinase inhibitors
The study of protein-protein interactions (PPIs) and the engineering of protein-based
inhibitors often employ two distinct strategies. One approach leverages the power of …
inhibitors often employ two distinct strategies. One approach leverages the power of …
Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14
Matrix metalloproteinases (MMPs) regulate the degradation of extracellular matrix (ECM)
components in biological processes. MMP activity is controlled by natural tissue inhibitors of …
components in biological processes. MMP activity is controlled by natural tissue inhibitors of …
[PDF][PDF] Maryam Raeeszadeh-Sarmazdeh1, Kerrie A. Greene1, Banumathi Sankaran2, Gregory P. Downey3
DC Radisky, ES Radisky - researchgate.net
Tissue inhibitors of metalloproteinases (TIMPs) are natural inhibitors of matrix
metalloproteinases (MMPs), enzymes that contribute to cancer and many inflammatory and …
metalloproteinases (MMPs), enzymes that contribute to cancer and many inflammatory and …