Maternal immune activation (mIA) during pregnancy is hypothesised to disrupt offspring
neurodevelopment and predispose offspring to neurodevelopmental disorders such as …

Animal models are useful preclinical tools for studying the pathogenesis of mental disorders
and the effectiveness of their treatment. While it is not possible to mimic all symptoms …

Due to an inability to ethically access developing human brain tissue as well as identify
prospective cases, early-arising neurodevelopmental and cell-specific signatures of …

Schizophrenia (Scz) is a brain disorder that has a typical onset in early adulthood but
otherwise maintains unknown disease origins. Unfortunately, little progress has been made …

Maternal immune activation (MIA) during pregnancy is an established environmental risk
factor for schizophrenia. Timing of immune activation exposure as well as sex of the …

Mothers exposed to infections during pregnancy disproportionally birth children who
develop autism and schizophrenia, disorders associated with altered GABAergic function …

It is widely accepted that narcotic use during pregnancy and specific environmental factors
(eg, maternal immune activation and chronic stress) may increase risk of neuropsychiatric …

Alterations in neocortical GABAergic interneurons (INs) have been affiliated with
neuropsychiatric diseases, including schizophrenia (SZ). Significant progress has been …

Schizophrenia (SZ) is a devastating psychiatric disorder affecting about 1% of the world's
population. Social-cognitive impairments in SZ prevent positive social interactions and lead …

The maternal polyinosinic: polycytidylic acid (poly (I: C)) animal model is frequently used to
study how maternal immune activation may impact neuro development in the offspring …