In rapidly adapting asexual populations, including many microbial pathogens and viruses,
numerous mutant lineages often compete for dominance within the population,,,–. These …

Neutral models of evolution assume the absence of natural selection. Formerly confined to
ecology and evolutionary biology, neutral models are spreading. In recent years they've …

Cancer cell lines are not homogeneous nor are they static in their genetic state and
biological properties. Genetic, transcriptional and phenotypic diversity within cell lines …

Allele frequency time series data constitute a powerful resource for unraveling mechanisms
of adaptation, because the temporal dimension captures important information about …

Resolving the role of natural selection is a basic objective of evolutionary biology. It is
generally difficult to detect the influence of selection because ubiquitous non-selective …

Sequencing the genomes of individual cancer cells provides the highest resolution of
intratumoral heterogeneity. To enable high throughput single cell DNA-Seq across …

Estimating recent effective population size is of great importance in characterizing and
predicting the evolution of natural populations. Methods based on nucleotide diversity may …

With the advent of deep sequencing techniques, it is now possible to track the evolution of
viruses with ever-increasing detail. Here, we present Flexible Inference from Time-Series …

Inferring Fitness Effects from Time-Resolved Sequence Data with a Delay-Deterministic
Model | Genetics | Oxford Academic Skip to Main Content Advertisement Oxford Academic …

The contemporary effective population size is important in many disciplines including
population genetics, conservation science and pest management. One of the most popular …