Iron is an essential component in many biological processes in the human body. It is critical
for the visual phototransduction cascade in the retina. However, excess iron can be toxic …

In the last half century, the life expectancy of beta-thalassemia patients has strikingly
increased mostly due to regular blood transfusions and chelation treatments. The improved …

Purpose.: Iron-induced oxidative stress may exacerbate age-related macular degeneration
(AMD). Ceruloplasmin/Hephaestin double-knockout (DKO) mice with age-dependent retinal …

Oxidative stress plays a key role in a light-damage (LD) model of retinal degeneration as
well as in age-related macular degeneration (AMD). Since iron can promote oxidative stress …

Deferoxamine is a chelating agent that has extended the life expectancy of patients with
thalassemia. In the 1980s, many investigators reported otologic and visual toxicity caused by …

BACKGROUND: Patients requiring chronic blood transfusions are at risk for iron overload,
which, if not treated by iron chelation therapy (ICT), can create serious organ damage and …

Background: Hearing disorders are reported in thalassemia patients treated with
deferoxamine. This study aimed to assess hearing loss in Iranian thalassemia major patients …

Ototoxicity due to iron chelation therapy, especially deferoxamine (DFO), is frequently
observed in patients who have a higher chelation index (> 0.025). However, there is limited …

OBJECTIVE: In this study, we aimed to detect the incidences of ototoxicity in patients with
hemoglobinopathies taking deferoxamine (DFO), deferiprone, and deferasirox using the …

The predictive value of pure-tone audiometry (PTA) in the early detection of ototoxicity has
been questioned, particularly in the higher frequencies. Otoacoustic emissions testing …