[HTML][HTML] Hepatitis B virus PreS/S gene variants: pathobiology and clinical implications
T Pollicino, I Cacciola, F Saffioti, G Raimondo - Journal of hepatology, 2014 - Elsevier
The emergence and takeover of hepatitis B virus (HBV) variants carrying mutation (s) in the
preS/S genomic region is a fairly frequent event that may occur spontaneously or may be the …
preS/S genomic region is a fairly frequent event that may occur spontaneously or may be the …
Hepatitis B virus genetic variability and evolution
A Kay, F Zoulim - Virus research, 2007 - Elsevier
Hepatitis B virus has been evolving gradually over a long period of time, resulting in a large
amount of genetic diversity, despite the constraints imposed by the complex genetic …
amount of genetic diversity, despite the constraints imposed by the complex genetic …
[HTML][HTML] Clinical significance of hepatitis B surface antigen mutants
N Coppola, L Onorato, C Minichini… - World journal of …, 2015 - ncbi.nlm.nih.gov
Hepatitis B virus (HBV) infection is a major public health problem in many countries, with
nearly 300 million people worldwide carrying HBV chronic infection and over 1 million …
nearly 300 million people worldwide carrying HBV chronic infection and over 1 million …
[HTML][HTML] Detecting hepatitis B surface antigen mutants
PF Coleman - Emerging infectious diseases, 2006 - ncbi.nlm.nih.gov
Hepatitis B viral mutants can emerge in patients as a result of selection pressure from either
immune response or treatment options. Mutations that occur within the immunodominant …
immune response or treatment options. Mutations that occur within the immunodominant …
Hepatitis B virus genetic diversity
JM Echevarría, A Avellón - Journal of medical virology, 2006 - Wiley Online Library
Hepatitis B virus (HBV) is a human DNA virus, which replicates through an RNA
intermediate because of the reverse‐transcriptase (RT) activity of its DNA polymerase. As a …
intermediate because of the reverse‐transcriptase (RT) activity of its DNA polymerase. As a …
N-glycosylation mutations within hepatitis B virus surface major hydrophilic region contribute mostly to immune escape
DM Yu, XH Li, V Mom, ZH Lu, XW Liao, Y Han… - Journal of …, 2014 - Elsevier
Background & Aims HBV immune escape represents a challenge to prevention, diagnosis,
and treatment of hepatitis B. Here, we analyzed the molecular and clinical characteristics of …
and treatment of hepatitis B. Here, we analyzed the molecular and clinical characteristics of …
The virological aspects of hepatitis B
ZS Valaydon, SA Locarnini - Best practice & research clinical …, 2017 - Elsevier
Human hepatitis B virus (HBV) is a hepatotropic virus that is responsible for a significant
burden of disease, causing liver disease and hepatocellular carcinoma. It is a small DNA …
burden of disease, causing liver disease and hepatocellular carcinoma. It is a small DNA …
[HTML][HTML] Quasispecies structure, cornerstone of hepatitis B virus infection: mass sequencing approach
Hepatitis B virus (HBV) is a DNA virus with complex replication, and high replication and
mutation rates, leading to a heterogeneous viral population. The population is comprised of …
mutation rates, leading to a heterogeneous viral population. The population is comprised of …
[HTML][HTML] Clinical relevance of hepatitis B virus variants
S Gao, ZP Duan, CS Coffin - World journal of hepatology, 2015 - ncbi.nlm.nih.gov
The hepatitis B virus (HBV) is a global public health problem with more than 240 million
people chronically infected worldwide, who are at risk for end-stage liver disease and …
people chronically infected worldwide, who are at risk for end-stage liver disease and …
No increase in prevalence of hepatitis B surface antigen mutant in a population of children and adolescents who were fully covered by universal infant immunization
HY Hsu, MH Chang, YH Ni, CL Chiang… - The Journal of …, 2010 - academic.oup.com
Background. Mutants of the a determinant of hepatitis B surface antigen (HBsAg) can
escape neutralization by vaccine-induced antibodies and prevail in an immunized …
escape neutralization by vaccine-induced antibodies and prevail in an immunized …