Background Per-and polyfluoroalkyl substances (PFAS) are of public health concern,
because of their ubiquitous and extremely persistent occurrence, and depending on their …

Perfluorinated and polyfluorinated compounds (PFASs) are a class of synthetic chemical
substances that are widely used in human production and life, such as fire-fighting foams …

The immune and skeletal systems share a variety of molecules, including cytokines,
chemokines, hormones, receptors, and transcription factors. Bone cells interact with immune …

Many cellular functions are regulated by calcium (Ca2+) signals that are generated by
different signaling pathways. One of these is the inositol 1, 4, 5-trisphosphate/calcium …

The gut microbiome is a key regulator of bone health that affects postnatal skeletal
development and skeletal involution. Alterations in microbiota composition and host …

Calcium (Ca2+) is an essential signaling molecule that controls a wide range of biological
functions. In the immune system, calcium signals play a central role in a variety of cellular …

The calcium signal is a powerful and multifaceted tool by which cells can achieve specific
outcomes. Cellular machinery important in tumour progression is often driven or influenced …

Nausea and vomiting are common gastrointestinal complaints that can be triggered by
diverse emetic stimuli through central and/or peripheral nervous systems. Both nausea and …

Calcium (Ca 2+) signals play fundamental roles in immune cell function. The main sources
of Ca 2+ influx in mammalian lymphocytes following antigen receptor stimulation are Ca 2+ …

Ion channels and transporters mediate the transport of charged ions across hydrophobic
lipid membranes. In immune cells, divalent cations such as calcium, magnesium, and zinc …