Highlights•Nucleotide metabolism.•Tumor microenvironment.•Immune cells.•Cancer
therapy.•Immunotherapy.Nucleotide metabolism plays a crucial role in the regulation of the …

Pancreatic ductal adenocarcinoma (PDAC) is the most common and aggressive type of
pancreatic cancer and has abysmal survival rates. In the past two decades …

Glucose is vital for life, serving as both a source of energy and carbon building block for
growth. When glucose is limiting, alternative nutrients must be harnessed. To identify …

From our daily nutrition and synthesis within cells, nucleosides enter the bloodstream and
circulate throughout the body and tissues. Nucleosides and nucleotides are classically …

Metabolic dysfunction-associated fatty liver disease (MAFLD) has a global prevalence of
about 25% and no approved therapy. Using metabolomic and proteomic analyses, we …

Tumours are heterogeneous tissues containing diverse populations of cells and an
abundant extracellular matrix (ECM). This tumour microenvironment prompts cancer cells to …

This commentary highlights the key recent advances made in the field of pancreatic cancer.
Although there has yet to be a major breakthrough in clinical care for the majority of patients …

Many individuals with cancer are resistant to immunotherapies. Here, we identify the gene
encoding the pyrimidine salvage pathway enzyme cytidine deaminase (CDA) among the top …

UPP1, a crucial pyrimidine metabolism-related enzyme, catalyzes the reversible
phosphorylation of uridine to uracil and ribose-1-phosphate. However, the effects of UPP1 in …

To rescue ischemic myocardium from progressing to myocardial infarction, timely
identification of the infarct size and reperfusion is crucial. However, fast and accurate …