The role of PI3K/AKT/mTOR signaling in hepatocellular carcinoma metabolism
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths in
the world. Metabolic reprogramming is considered a new hallmark of cancer, but it remains …
the world. Metabolic reprogramming is considered a new hallmark of cancer, but it remains …
Targeting Akt in cancer for precision therapy
H Hua, H Zhang, J Chen, J Wang, J Liu… - Journal of Hematology & …, 2021 - Springer
Biomarkers-guided precision therapeutics has revolutionized the clinical development and
administration of molecular-targeted anticancer agents. Tailored precision cancer therapy …
administration of molecular-targeted anticancer agents. Tailored precision cancer therapy …
Akt signaling pathway in macrophage activation and M1/M2 polarization
E Vergadi, E Ieronymaki, K Lyroni… - The Journal of …, 2017 - journals.aai.org
Macrophages become activated initiating innate immune responses. Depending on the
signals, macrophages obtain an array of activation phenotypes, described by the broad …
signals, macrophages obtain an array of activation phenotypes, described by the broad …
Noninvasive tests accurately identify advanced fibrosis due to NASH: baseline data from the STELLAR trials
Accurate noninvasive tests (NITs) are needed to replace liver biopsy for identifying
advanced fibrosis caused by nonalcoholic steatohepatitis (NASH). We analyzed screening …
advanced fibrosis caused by nonalcoholic steatohepatitis (NASH). We analyzed screening …
Role of nonresolving inflammation in hepatocellular carcinoma development and progression
LX Yu, Y Ling, HY Wang - NPJ precision oncology, 2018 - nature.com
Hepatocellular carcinoma (HCC) has become a leading cause of cancer-related death,
making the elucidation of its underlying mechanisms an urgent priority. Inflammation is an …
making the elucidation of its underlying mechanisms an urgent priority. Inflammation is an …
Akt signaling in macrophage polarization, survival, and atherosclerosis
MRF Linton, JJ Moslehi, VR Babaev - International journal of molecular …, 2019 - mdpi.com
The PI3K/Akt pathway plays a crucial role in the survival, proliferation, and migration of
macrophages, which may impact the development of atherosclerosis. Changes in Akt …
macrophages, which may impact the development of atherosclerosis. Changes in Akt …
Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin
Hepatocellular carcinoma (HCC) cells are metabolically distinct from normal hepatocytes by
expressing the high-affinity hexokinase (HK2) and suppressing glucokinase (GCK). This is …
expressing the high-affinity hexokinase (HK2) and suppressing glucokinase (GCK). This is …
Chen et al.
S Chen, Z Wang, M Zhang, X Shi, L Wang… - Carbon …, 2023 - search.proquest.com
With the increasing market demand for high-performance lithium-ion batteries with high-
capacity electrode materials, reducing the irreversible capacity loss in the initial cycle and …
capacity electrode materials, reducing the irreversible capacity loss in the initial cycle and …
Targeting 7-dehydrocholesterol reductase integrates cholesterol metabolism and IRF3 activation to eliminate infection
J Xiao, W Li, X Zheng, L Qi, H Wang, C Zhang, X Wan… - Immunity, 2020 - cell.com
Recent work suggests that cholesterol metabolism impacts innate immune responses
against infection. However, the key enzymes or the natural products and mechanisms …
against infection. However, the key enzymes or the natural products and mechanisms …
[PDF][PDF] The mTORC2‐Akt1 cascade is crucial for c‐Myc to promote hepatocarcinogenesis in mice and humans
Z Xu, M Xu, P Liu, S Zhang, R Shang, Y Qiao… - …, 2019 - Wiley Online Library
Hepatocellular carcinoma (HCC) is a deadly form of liver cancer with limited treatment
options. The c‐Myc transcription factor is a pivotal player in hepatocarcinogenesis, but the …
options. The c‐Myc transcription factor is a pivotal player in hepatocarcinogenesis, but the …