MicroRNAs in spermatogenesis dysfunction and male infertility: clinical phenotypes, mechanisms and potential diagnostic biomarkers

Z Shi, M Yu, T Guo, Y Sui, Z Tian, X Ni… - Frontiers in …, 2024 - frontiersin.org
Infertility affects approximately 10–15% of couples worldwide who are attempting to
conceive, with male infertility accounting for 50% of infertility cases. Male infertility is related …

Using microRNAs as molecular biomarkers for the evaluation of male infertility

R Asadpour, E Mofidi Chelan - Andrologia, 2022 - Wiley Online Library
Infertility is a multiplex disorder in the reproductive system, and men are responsible for
more than half of the cases. Nowadays, semen analysis has been considered the critical …

Small noncoding RNAs and sperm nuclear basic proteins reflect the environmental impact on germ cells

G Ferrero, R Festa, L Follia, G Lettieri, S Tarallo… - Molecular …, 2024 - Springer
Background Molecular techniques can complement conventional spermiogram analyses to
provide new information on the fertilizing potential of spermatozoa and to identify early …

Expression of SPAG7 and its regulatory microRNAs in seminal plasma and seminal plasma-derived extracellular vesicles of patients with subfertility

M Abu-Halima, LS Becker, MA Al Smadi, LS Kunz… - Scientific Reports, 2023 - nature.com
Seminal plasma contains a variety of extracellular vesicles (EVs) that deliver RNAs including
microRNAs (miRNAs) molecules. However, the roles of these EVs along with their delivered …

MicroRNA-targeting in male infertility: Sperm microRNA-19a/b-3p and its spermatogenesis related transcripts content in men with oligoasthenozoospermia

M Abu-Halima, LS Becker, BM Ayesh… - Frontiers in Cell and …, 2022 - frontiersin.org
Objective: To elucidate and validate the potential regulatory function of miR-19a/b-3p and its
spermatogenesis-related transcripts content in sperm samples collected from men with …

Proteomic landscape of human sperm in patients with different spermatogenic impairments

LS Becker, MA Al Smadi, M Raeschle, S Rishik… - Cells, 2023 - mdpi.com
Although the proteome of sperm has been characterized, there is still a lack of high-
throughput studies on dysregulated proteins in sperm from subfertile men, with only a few …

Characterization of micro-RNA in women with different ovarian reserve

M Abu-Halima, LS Becker, BM Ayesh, SL Baus… - Scientific Reports, 2021 - nature.com
Women undergoing infertility treatment are routinely subjected to one or more tests of
ovarian reserve. Therefore, an adequate assessment of the ovarian reserve is necessary for …

Towards a more comprehensive picture of the microRNA-23a/b-3p impact on impaired male fertility

LS Becker, MA Al Smadi, H Koch, H Abdul-Khaliq… - Biology, 2023 - mdpi.com
Simple Summary This study focused on the relationship between microRNA-23a/b-3p and
genes involved in human spermatogenesis, with the aim of understanding how this …

Sperm Motility Annotated Genes: Are They Associated with Impaired Fecundity?

M Abu-Halima, LS Becker, MA Al Smadi… - Cells, 2023 - mdpi.com
Sperm motility is a prerequisite for achieving pregnancy, and alterations in sperm motility,
along with sperm count and morphology, are commonly observed in subfertile men. The aim …

Lycopene inhibits apoptosis of mouse spermatocytes in varicocele via miR-23a/b-induced downregulation of PROK2

H Wang, B Zhu, T Jing, L Yu, K Zhang… - Reproduction, Fertility …, 2024 - CSIRO Publishing
Context. The varicocele is the leading cause of male infertility and can impair sperm quality
and testicular function through various mechanisms. In our previous study, we found the …