Cannabidiol (CBD) is one of the main pharmacologically active phytocannabinoids of
Cannabis sativa L. CBD is non-psychoactive but exerts a number of beneficial …

Calcium (Ca2+) is an essential signaling molecule that controls a wide range of biological
functions. In the immune system, calcium signals play a central role in a variety of cellular …

Background The neuroinflammatory response following traumatic brain injury (TBI) is known
to be a key secondary injury factor that can drive ongoing neuronal injury. Despite this …

It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …

Oxytocin is a nonapeptide hormone that has a central role in the regulation of parturition and
lactation. In this review, we address oxytocin receptor (OTR) signalling and its role in the …

Abstract Stromal interacting molecule 1 (STIM1) is a Ca2+ sensor that conveys the Ca2+
load of the endoplasmic reticulum to store-operated channels (SOCs) at the plasma …

TRPM7, a divalent cation-selective channel with kinase domains, has been widely reported
to potentially affect cancers. In this study, we conducted multiple bioinformatic analyses …

Abstract Background: Transient Receptor Potential (TRP) channels are expressed in many
solid tumors. However, their expression in breast cancer remains largely unknown. Here, we …

One of the systems responsible for maintaining cellular redox homeostasis is the thioredoxin-
dependent system. An equally important function of this system is the regulation of the …

Disruption of the alveolar septal barrier leads to acute lung injury, patchy alveolar flooding,
and hypoxemia. Although calcium entry into endothelial cells is critical for loss of barrier …