Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in ageing,
affecting around 46 million people worldwide but few treatments are currently available. The …

Although Alzheimer's disease is the most pervasive neurodegenerative disorder, the
mechanism underlying its development is still not precisely understood. Available data …

Creating cellular homeostasis within a defined tissue typically relates to the processes of
apoptosis and efferocytosis. A great example here is cell debris that must be removed to …

Autophagy is a proposed route of amyloid-β (Aβ) clearance by microglia that is halted in
Alzheimer's Disease (AD), though mechanisms underlying this dysfunction remain elusive …

Age-associated microglial dysfunction contributes to the accumulation of amyloid-β (Aβ)
plaques in Alzheimer's disease. Although several studies have shown age-related declines …

Efferocytosis (clearance of apoptotic cells by phagocytosis without inducing inflammation
and autoimmunity) is an important mechanism in the resolution of inflammatory processes …

When tumor cells are killed by targeted therapy, radiotherapy, or chemotherapy, they trigger
their primary tumor by releasing pro-inflammatory cytokines. Microenvironmental …

The effective clearance of apoptotic cells is essential for maintaining central nervous system
(CNS) homeostasis and restoring homeostasis after injury. In most cases of physiological …

Microglia are resident immune cells in the central nervous system. During the pathogenesis
of Alzheimer's disease, stimulatory factors continuously act on the microglia causing …

The amyloid beta (Aβ) plaques found in Alzheimer's disease (AD) patients' brains contain
collagens and are embedded extracellularly. Several collagens have been proposed to …