Tissue and plasma proteomics for early stage cancer detection

L Peng, DI Cantor, C Huang, K Wang, MS Baker… - Molecular omics, 2018 - pubs.rsc.org
The pursuit of novel and effective biomarkers is essential in the struggle against cancer,
which is a leading cause of mortality worldwide. Biomarkers can be used as specific …

Protein content and functional characteristics of serum‐purified exosomes from patients with colorectal cancer revealed by quantitative proteomics

Y Chen, Y Xie, L Xu, S Zhan, Y Xiao… - … journal of cancer, 2017 - Wiley Online Library
Tumor cells of colorectal cancer (CRC) release exosomes into the circulation. These
exosomes can mediate communication between cells and affect various tumor‐related …

Mass Spectrometry-Based N-Glycomics of Colorectal Cancer

MK Sethi, S Fanayan - International journal of molecular sciences, 2015 - mdpi.com
Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. An increased
molecular understanding of the CRC pathology is warranted to gain insights into the …

Protein Paucimannosylation Is an Enriched N‐Glycosylation Signature of Human Cancers

S Chatterjee, LY Lee, R Kawahara, JL Abrahams… - …, 2019 - Wiley Online Library
While aberrant protein glycosylation is a recognized characteristic of human cancers,
advances in glycoanalytics continue to discover new associations between glycoproteins …

THBS1 facilitates colorectal liver metastasis through enhancing epithelial–mesenchymal transition

X Liu, D Xu, Z Liu, Y Li, C Zhang, Y Gong… - Clinical and …, 2020 - Springer
Objective Liver metastasis is one of the major causes of cancer-related death in patients with
colorectal cancer (CRC). The purpose of this study was to identify specific molecules which …

In-depth N-glycome profiling of paired colorectal cancer and non-tumorigenic tissues reveals cancer-, stage- and EGFR-specific protein N-glycosylation

MK Sethi, H Kim, CK Park, MS Baker, YK Paik… - …, 2015 - academic.oup.com
Glycomics may assist in uncovering the structure–function relationships of protein
glycosylation and identify glycoprotein markers in colorectal cancer (CRC) research. Herein …

Age-associated proteomic signatures and potential clinically actionable targets of colorectal cancer

Y Gong, Y Liu, T Wang, Z Li, L Gao, H Chen… - Molecular & Cellular …, 2021 - ASBMB
The occurrence and prevalence of colorectal cancer (CRC) is closely associated with age.
More than 90% of patients with CRC are diagnosed after 50 years of age. However, CRC …

Integrated meta-analysis of colorectal cancer public proteomic datasets for biomarker discovery and validation

J Robles, A Prakash, JA Vizcaíno… - PLOS Computational …, 2024 - journals.plos.org
The cancer biomarker field has been an object of thorough investigation in the last decades.
Despite this, colorectal cancer (CRC) heterogeneity makes it challenging to identify and …

Alignstein: Optimal transport for improved LC-MS retention time alignment

G Skoraczyński, A Gambin, B Miasojedow - GigaScience, 2022 - academic.oup.com
Background Reproducibility of liquid chromatography separation is limited by retention time
drift. As a result, measured signals lack correspondence over replicates of the liquid …

Isolation and proteomic profiling of urinary exosomes from patients with colorectal cancer

L Ma, H Yu, Y Zhu, K Xu, A Zhao, L Ding, H Gao… - Proteome Science, 2023 - Springer
Exosomes in the body fluid are effective cell-derived membranous structures transferring
various molecules to mediate intercellular communication. The expression of protein in the …