[HTML][HTML] Current concepts and treatments of schizophrenia
P Stępnicki, M Kondej, AA Kaczor - Molecules, 2018 - mdpi.com
Schizophrenia is a debilitating mental illness which involves three groups of symptoms, ie,
positive, negative and cognitive, and has major public health implications. According to …
positive, negative and cognitive, and has major public health implications. According to …
Epigenetic basis of mental illness
Psychiatric disorders are complex multifactorial illnesses involving chronic alterations in
neural circuit structure and function as well as likely abnormalities in glial cells. While …
neural circuit structure and function as well as likely abnormalities in glial cells. While …
Animal models of schizophrenia
CA Jones, DJG Watson… - British journal of …, 2011 - Wiley Online Library
Developing reliable, predictive animal models for complex psychiatric disorders, such as
schizophrenia, is essential to increase our understanding of the neurobiological basis of the …
schizophrenia, is essential to increase our understanding of the neurobiological basis of the …
Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes
U Rudolph, F Knoflach - Nature reviews Drug discovery, 2011 - nature.com
GABAA (γ-aminobutyric acid, type A) receptors are a family of ligand-gated ion channels that
are essential for the regulation of central nervous system function. Benzodiazepines—which …
are essential for the regulation of central nervous system function. Benzodiazepines—which …
Evidence for the risks and consequences of adolescent cannabis exposure
Objective This review of the scientific literature examines the potential adult sequelae of
exposure to cannabis and related synthetic cannabinoids in adolescence. We examine the …
exposure to cannabis and related synthetic cannabinoids in adolescence. We examine the …
GABAergic interneuron origin of schizophrenia pathophysiology
K Nakazawa, V Zsiros, Z Jiang, K Nakao, S Kolata… - …, 2012 - Elsevier
Hypofunction of N-methyl-d-aspartic acid-type glutamate receptors (NMDAR) induced by the
systemic administration of NMDAR antagonists is well known to cause schizophrenia-like …
systemic administration of NMDAR antagonists is well known to cause schizophrenia-like …
[HTML][HTML] Towards a better understanding of GABAergic remodeling in Alzheimer's disease
K Govindpani, B Calvo-Flores Guzmán… - International journal of …, 2017 - mdpi.com
γ-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the vertebrate brain.
In the past, there has been a major research drive focused on the dysfunction of the …
In the past, there has been a major research drive focused on the dysfunction of the …
GABAA Receptor Subtypes: Therapeutic Potential in Down Syndrome, Affective Disorders, Schizophrenia, and Autism
U Rudolph, H Möhler - Annual review of pharmacology and …, 2014 - annualreviews.org
The γ-aminobutyric acid (GABA) system plays a pivotal role in orchestrating the
synchronicity of local networks and the functional coupling of different brain regions. Here …
synchronicity of local networks and the functional coupling of different brain regions. Here …
Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression
PV Choudary, M Molnar, SJ Evans… - Proceedings of the …, 2005 - National Acad Sciences
Abnormalities in l-glutamic acid (glutamate) and GABA signal transmission have been
postulated to play a role in depression, but little is known about the underlying molecular …
postulated to play a role in depression, but little is known about the underlying molecular …
[HTML][HTML] The dynamics of DNA methylation in schizophrenia and related psychiatric disorders
DR Grayson, A Guidotti - Neuropsychopharmacology, 2013 - nature.com
Major psychiatric disorders such as schizophrenia (SZ) and bipolar disorder (BP) with
psychosis (BP+) express a complex symptomatology characterized by positive symptoms …
psychosis (BP+) express a complex symptomatology characterized by positive symptoms …