Tetrazoles via multicomponent reactions

CG Neochoritis, T Zhao, A Domling - Chemical reviews, 2019 - ACS Publications
Tetrazole derivatives are a prime class of heterocycles, very important to medicinal
chemistry and drug design due to not only their bioisosterism to carboxylic acid and amide …

Synthesis of polyheterocycles via multicomponent reactions

IA Ibarra, A Islas-Jácome… - Organic & Biomolecular …, 2018 - pubs.rsc.org
Polyheterocycles are one of the most desired synthetic targets due to their numerous and
valuable applications in various fields. Multicomponent reactions (MCRs) are highly …

Synthetic approaches to 3-(2-nitroalkyl) indoles and their use to access tryptamines and related bioactive compounds

S Lancianesi, A Palmieri, M Petrini - Chemical Reviews, 2014 - ACS Publications
The assembly of architecturally complex alkaloids embedding the indole nucleus is of
paramount importance for the target oriented synthesis of biologically active molecules. 1 A …

Recent advances in the application of indoles in multicomponent reactions

GM Ziarani, R Moradi, T Ahmadi, N Lashgari - RSC advances, 2018 - pubs.rsc.org
Indoles are some of the most versatile and common nitrogen-based heterocyclic scaffolds
and are frequently used in the synthesis of various organic compounds. Indole based …

Microwave-assisted post-Ugi reactions for the synthesis of polycycles

L Song, L Cai, EV Van der Eycken - Molecules, 2022 - mdpi.com
Microwave irradiation and post-Ugi reactions own their respective advantages in
comparison with other strategies. The combination of microwave irradiation and post-Ugi …

One‐Pot Construction of Bis‐Heterocycles through Isocyanide Based Multicomponent Reactions

S Ishwar Bhat - ChemistrySelect, 2020 - Wiley Online Library
Bis‐heterocycles (BHCs) are hybrid molecules comprising two linked, bound, spacer, or
fused heterocyclic skeletons. In recent years, these compounds have attracted increased …

Synthesis of indolo/pyrroloazepinone-oxindoles as potential cytotoxic, DNA-intercalating and Topo I inhibitors

M Kadagathur, AS Shaikh, B Panda, J George… - Bioorganic …, 2022 - Elsevier
A series of 17 indolo/pyrroloazepinone-oxindole conjugates was synthesized and evaluated
for their antiproliferative activity against a panel of selected human cancer cell lines …

Synthesis of seven-membered nitrogen heterocycles through the Ugi multicomponent reaction

L Banfi, A Basso, C Lambruschini, L Moni… - Chemistry of Heterocyclic …, 2017 - Springer
This paper reviews all the syntheses of 7-membered nitrogen heterocycles that are based
on the Ugi multicomponent reaction. Different systems may be obtained in a diversity …

Synthesis of 3-tetrazolylmethyl-4H-chromen-4-ones via Ugi-azide and biological evaluation against Entamoeba histolytica, Giardia lamblia and Trichomona vaginalis

PA Cano, A Islas-Jácome, J González-Marrero… - Bioorganic & Medicinal …, 2014 - Elsevier
The synthesis of novel 3-tetrazolylmethyl-4H-chromen-4-ones via an Ugi-azide
multicomponent reaction and their biological evaluation against Entamoeba histolytica …

High Rotational Barrier Atropisomers

M Fragkiadakis, M Thomaidi… - … A European Journal, 2024 - Wiley Online Library
Atropisomers have attracted a great deal of attention lately due to their numerous
applications in organic synthesis and to their employment in drug discovery. However, the …