The role of p53 signaling in colorectal cancer

MC Liebl, TG Hofmann - Cancers, 2021 - mdpi.com
Simple Summary The transcription factor p53 is a crucial tumor suppressor that regulates
diverse cellular responses to protect against cancer development. Deactivating p53 …

Noncoding RNAs as regulators of STAT3 pathway in gastrointestinal cancers: Roles in cancer progression and therapeutic response

M Ashrafizadeh, CD Mohan… - Medicinal research …, 2023 - Wiley Online Library
Gastrointestinal (GI) tumors (cancers of the esophagus, gastric, liver, pancreas, colon, and
rectum) contribute to a large number of deaths worldwide. STAT3 is an oncogenic …

microRNAs: new prognostic, diagnostic, and therapeutic biomarkers in cervical cancer

JS Nahand, S Taghizadeh‐boroujeni… - Journal of cellular …, 2019 - Wiley Online Library
Cervical cancer is as a kind of cancer beginning from the cervix. Given that cervical cancer
could be observed in women who infected with papillomavirus, regular oral contraceptives …

Colorectal cancer: Genetic alterations, novel biomarkers, current therapeutic strategies and clinical trials

M Housini, B Dariya, N Ahmed, A Stevens, H Fiadjoe… - Gene, 2024 - Elsevier
Colorectal cancer (CRC) is the third most commonly detected cancer with a serious global
health issue. The rates for incidence and mortality for CRC are alarming, especially since …

Interactions among lncRNAs, miRNAs and mRNA in colorectal cancer

XJ Tang, W Wang, SS Hann - Biochimie, 2019 - Elsevier
Long non-coding RNAs (lncRNAs) are longer than 200 nts non-coding transcripts and have
recently emerged as one of the largest and significantly diverse RNA families whereas …

The HOTAIR/miR-214/ST6GAL1 crosstalk modulates colorectal cancer procession through mediating sialylated c-Met via JAK2/STAT3 cascade

B Liu, Q Liu, S Pan, Y Huang, Y Qi, S Li, Y Xiao… - Journal of Experimental …, 2019 - Springer
Background The regulatory non-coding RNAs, including long non-coding RNAs (lncRNAs)
and microRNAs (miRNAs), emerge as pivotal markers during tumor progression. Abnormal …

STAT3 as a newly emerging target in colorectal cancer therapy: Tumorigenesis, therapy response, and pharmacological/nanoplatform strategies

M Hashemi, S Abbaszadeh, M Rashidi, N Amini… - Environmental …, 2023 - Elsevier
Colorectal cancer (CRC) ranks as the third most aggressive tumor globally, and it can be
categorized into two forms: colitis-mediated CRC and sporadic CRC. The therapeutic …

[HTML][HTML] Role of epigenetics in transformation of inflammation into colorectal cancer

ZH Yang, YQ Dang, G Ji - World journal of gastroenterology, 2019 - ncbi.nlm.nih.gov
Molecular mechanisms associated with inflammation-promoted tumorigenesis have become
an important topic in cancer research. Various abnormal epigenetic changes, including DNA …

Interplay of miRNAs and lncRNAs in STAT3 signaling pathway in colorectal cancer progression

O Rahbar Farzam, S Najafi, M Amini, Z Rahimi… - Cancer Cell …, 2024 - Springer
In recent decades, colorectal cancer (CRC) has turned into one of the most widespread
malignancies, and the incidence of this malignancy is expected to increase. Despite …

Long non‐coding RNA LINC01535 promotes cervical cancer progression via targeting the miR‐214/EZH2 feedback loop

H Song, Y Liu, X Jin, Y Liu, Y Yang, L Li… - Journal of cellular …, 2019 - Wiley Online Library
Long non‐coding RNAs (lncRNAs) have shown critical roles in multiple cancers via
competitively binding common microRNAs. miR‐214 has been proved to play tumour …