Clinical instrumentation and applications of Raman spectroscopy

I Pence, A Mahadevan-Jansen - Chemical Society Reviews, 2016 - pubs.rsc.org
Clinical diagnostic devices provide new sources of information that give insight about the
state of health which can then be used to manage patient care. These tools can be as simple …

Raman spectroscopy for cancer detection and cancer surgery guidance: translation to the clinics

IP Santos, EM Barroso, TCB Schut, PJ Caspers… - Analyst, 2017 - pubs.rsc.org
Oncological applications of Raman spectroscopy have been contemplated, pursued, and
developed at academic level for at least 25 years. Published studies aim to detect pre …

Raman spectroscopy and imaging in bioanalytics

D Cialla-May, C Krafft, P Rösch… - Analytical …, 2021 - ACS Publications
Since the discovery of the inelastic scattering of light, ie, the so-called Raman effect, 1
Raman spectroscopy has become an attractive tool in a high number of research fields …

Raman spectroscopy: guiding light for the extracellular matrix

MS Bergholt, A Serio, MB Albro - Frontiers in bioengineering and …, 2019 - frontiersin.org
The extracellular matrix (ECM) consists of a complex mesh of proteins, glycoproteins, and
glycosaminoglycans, and is essential for maintaining the integrity and function of biological …

High-throughput molecular imaging via deep-learning-enabled Raman spectroscopy

CC Horgan, M Jensen, A Nagelkerke… - Analytical …, 2021 - ACS Publications
Raman spectroscopy enables nondestructive, label-free imaging with unprecedented
molecular contrast, but is limited by slow data acquisition, largely preventing high …

Raman spectroscopy and chemometrics: A potential universal method for diagnosing cancer

NM Ralbovsky, IK Lednev - Spectrochimica Acta Part A: Molecular and …, 2019 - Elsevier
Cancer is the second-leading cause of death worldwide. It affects an unfathomable number
of people, with almost 16 million Americans currently living with it. While many cancers can …

Application of vibrational spectroscopy and imaging to point-of-care medicine: a review

S Pahlow, K Weber, J Popp, BR Wood… - Applied …, 2018 - journals.sagepub.com
Vibrational spectroscopy and imaging promise molecular information that can be rapidly
acquired without the need for specialized stains or dyes, thereby potentially simplifying and …

Optical spectroscopy for in vivo medical diagnosis—a review of the state of the art and future perspectives

JA Kim, DJ Wales, GZ Yang - Progress in Biomedical …, 2020 - iopscience.iop.org
When light is incident to a biological tissue surface, combinations of optical processes occur,
such as reflection, absorption, elastic and non-elastic scattering, and fluorescence. Analysis …

Advances in real‐time fiber‐optic Raman spectroscopy for early cancer diagnosis: Pushing the frontier into clinical endoscopic applications

HPS Heng, C Shu, W Zheng, K Lin… - Translational …, 2021 - Wiley Online Library
Real‐time fiber‐optic Raman spectroscopy has emerged as a compelling approach for
biomedical diagnosis and characterization. This article reviews the following topics related …

Raman spectroscopic imaging for quantification of depth-dependent and local heterogeneities in native and engineered cartilage

MB Albro, MS Bergholt, JP St-Pierre… - NPJ Regenerative …, 2018 - nature.com
Articular cartilage possesses a remarkable, mechanically-robust extracellular matrix (ECM)
that is organized and distributed throughout the tissue to resist physiologic strains and …