The proteins of mRNA modification: writers, readers, and erasers
MN Flamand, M Tegowski… - Annual review of …, 2023 - annualreviews.org
Over the past decade, mRNA modifications have emerged as important regulators of gene
expression control in cells. Fueled in large part by the development of tools for detecting …
expression control in cells. Fueled in large part by the development of tools for detecting …
Cellular pathways influenced by protein arginine methylation: Implications for cancer
Arginine methylation is an influential post-translational modification occurring on histones,
RNA binding proteins, and many other cellular proteins, affecting their function by altering …
RNA binding proteins, and many other cellular proteins, affecting their function by altering …
Methyltransferase-like proteins in cancer biology and potential therapeutic targeting
YN Qi, Z Liu, LL Hong, P Li, ZQ Ling - Journal of Hematology & Oncology, 2023 - Springer
RNA modification has recently become a significant process of gene regulation, and the
methyltransferase-like (METTL) family of proteins plays a critical role in RNA modification …
methyltransferase-like (METTL) family of proteins plays a critical role in RNA modification …
The competitive landscape of the dsRNA world
KA Cottrell, RJ Andrews, BL Bass - Molecular Cell, 2024 - cell.com
The ability to sense and respond to infection is essential for life. Viral infection produces
double-stranded RNAs (dsRNAs) that are sensed by proteins that recognize the structure of …
double-stranded RNAs (dsRNAs) that are sensed by proteins that recognize the structure of …
METTL3 protects METTL14 from STUB1‐mediated degradation to maintain m6A homeostasis
ZC Zeng, Q Pan, YM Sun, HJ Huang, XT Chen… - EMBO …, 2023 - embopress.org
Abstract N 6‐Methyladenosine (m6A) is an important RNA modification catalyzed by
methyltransferase‐like 3 (METTL3) and METTL14. m6A homeostasis mediated by the …
methyltransferase‐like 3 (METTL3) and METTL14. m6A homeostasis mediated by the …
The functions and mechanisms of post-translational modification in protein regulators of RNA methylation: Current status and future perspectives
Y Chen, Z Jiang, Y Yang, C Zhang, H Liu… - International Journal of …, 2023 - Elsevier
RNA methylation, an epigenetic modification that does not alter gene sequence, may be
important to diverse biological processes. Protein regulators of RNA methylation include …
important to diverse biological processes. Protein regulators of RNA methylation include …
Recognition of G-quadruplex RNA by a crucial RNA methyltransferase component, METTL14
A Yoshida, T Oyoshi, A Suda, S Futaki… - Nucleic acids …, 2022 - academic.oup.com
Abstract N 6-methyladenosine (m6A) is an important epitranscriptomic chemical modification
that is mainly catalyzed by the METTL3/METTL14 RNA methyltransferase heterodimer …
that is mainly catalyzed by the METTL3/METTL14 RNA methyltransferase heterodimer …
[HTML][HTML] PRMT1 methylates METTL14 to modulate its oncogenic function
Abstract N6-methyladenosine (m6A), the most abundant mRNA modification in mammalian
cells, is responsible for mRNA stability and alternative splicing. The METTL3-METTL14 …
cells, is responsible for mRNA stability and alternative splicing. The METTL3-METTL14 …
m6A governs length-dependent enrichment of mRNAs in stress granules
Stress granules are biomolecular condensates composed of protein and mRNA. One feature
of stress granule-enriched mRNAs is that they are often longer than average. Another …
of stress granule-enriched mRNAs is that they are often longer than average. Another …
Insights into roles of METTL14 in tumors
X Liu, Y Du, Z Huang, H Qin, J Chen, Y Zhao - Cell proliferation, 2022 - Wiley Online Library
Abstract N6‐Methyladenosine (m6A) is considered the most common and endogenous
modification of eukaryotic RNAs. Highly conserved in many species, m6A regulates RNA …
modification of eukaryotic RNAs. Highly conserved in many species, m6A regulates RNA …