A comprehensive summary of LL-37, the factotum human cathelicidin peptide

D Vandamme, B Landuyt, W Luyten, L Schoofs - Cellular immunology, 2012 - Elsevier
Cathelicidins are a group of antimicrobial peptides. Since their discovery, it has become
clear that they are an exceptional class of peptides, with some members having pleiotropic …

Little peptide, big effects: the role of LL-37 in inflammation and autoimmune disease

JM Kahlenberg, MJ Kaplan - The Journal of Immunology, 2013 - journals.aai.org
The innate immune system utilizes many approaches for defense against invading
microorganisms, including complement-mediated lysis, engulfment, formation of neutrophil …

Cathelicidins modulate TLR-activation and inflammation

MR Scheenstra, RM Van Harten… - Frontiers in …, 2020 - frontiersin.org
Cathelicidins are short cationic peptides that are part of the innate immune system. At first,
these peptides were studied mostly for their direct antimicrobial killing capacity, but …

[HTML][HTML] Pancreatic β-cells limit autoimmune diabetes via an immunoregulatory antimicrobial peptide expressed under the influence of the gut microbiota

J Sun, L Furio, R Mecheri, AM van der Does… - Immunity, 2015 - cell.com
Antimicrobial peptides (AMPs) expressed by epithelial and immune cells are largely
described for the defense against invading microorganisms. Recently, their …

Cathelicidin impact on inflammatory cells

J Agier, M Efenberger… - Central European Journal …, 2015 - termedia.pl
Cathelicidins, like other antimicrobial peptides, exhibit direct antimicrobial activities against
a broad spectrum of microbes, including both Gram-positive and Gram-negative bacteria …

Significance of LL‐37 on immunomodulation and disease outcome

B Yang, D Good, T Mosaiab, W Liu, G Ni… - BioMed Research …, 2020 - Wiley Online Library
LL‐37, also called cathelicidin, is an important part of the human immune system, which can
resist various pathogens. A plethora of experiments have demonstrated that it has the …

Antimicrobial peptides: clinical relevance and therapeutic implications

FP da Silva, MCC Machado - Peptides, 2012 - Elsevier
Antimicrobial peptides (AMPs) are molecules that provide protection against environmental
pathogens, acting against a large number of microorganisms, including bacteria, fungi …

Unique features of human cathelicidin LL‐37

K Bandurska, A Berdowska, R Barczyńska‐Felusiak… - Biofactors, 2015 - Wiley Online Library
Cathelicidins are antimicrobial peptides produced by humans and animals in response to
various pathogenic microbes. This review intends to provide a brief overview of the …

The antimicrobial peptide cathelicidin modulates Clostridium difficile-associated colitis and toxin A-mediated enteritis in mice

TC Hing, S Ho, DQ Shih, R Ichikawa, M Cheng, J Chen… - Gut, 2013 - gut.bmj.com
Background Clostridium difficile mediates intestinal inflammation by releasing toxin A (TxA),
a potent enterotoxin. Cathelicidins (Camp as gene name, LL-37 peptide in humans and …

Cathelicidin-mediated lipopolysaccharide signaling via intracellular TLR4 in colonic epithelial cells evokes CXCL8 production

R Holani, A Babbar, GAD Blyth, F Lopes, H Jijon… - Gut …, 2020 - Taylor & Francis
We hypothesized that the antimicrobial peptide cathelicidin has a physiological role in
regulating gut inflammatory homeostasis. We determined that cathelicidin synergizes with …