A constant supply of oxygen is indispensable for cardiac viability and function. However, the
role of oxygen and oxygen-associated processes in the heart is complex, and they and can …

Human serum albumin (HSA) regulates the transport and availability of numerous chemical
compounds and molecules in the blood vascular system. While previous HSA research has …

Nitrite is one of the players in the broad nitrogen biogeochemical cycle. This nitrogen oxo-
anion is involved in key pathways crucial to life on Earth and to the planetary “recycling” of …

The thioredoxin (Trx) system comprises Trx, truncated Trx (Trx-80), Trx reductase, and
NADPH, besides a natural Trx inhibitor, the thioredoxin-interacting protein (TXNIP). This …

The role of reactive oxygen and nitrogen species in local and systemic defense reactions is
well documented. NPR1 and TGA1 are key redox-controlled regulators of systemic acquired …

Increased oxidative stress plays an important role in the pathophysiology of cardiovascular
diseases such as hypertension, atherosclerosis, diabetes, cardiac hypertrophy, heart failure …

Background & Aims: Barrier functions across epithelia and endothelia are essential for
homeostatic tissue regulation. Astroglia interact with cerebral endothelia to maintain the …

Neurodegenerative disorders like Alzheimer's disease and Parkinson's disease are
characterized by progressive degeneration of synapses and neurons. Accumulation of …

Summary Hypoxia-inducible factor 1 (HIF-1) is a master transcriptional factor. Under normal
oxygen tension, HIF-1 activity is usually suppressed due to the rapid, oxygen-dependent …

All life requires nitrogen compounds. Nitrite is such a compound that is naturally occurring in
nature and biology. Over the years, the pharmacological stance on nitrite has undergone a …