The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome
biogenesis is the process that generates ribosomes and plays an essential role in cell …

Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell
growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the …

Despite several decades of intense research focused on understanding function (s) and
disease-associated malfunction of p53, there is no sign of any “mid-life crisis” in this rapidly …

The tumor-suppressive activity of p53 is largely attributed to its ability to induce cell death,
including apoptosis, through transcription-dependent and transcription-independent …

Rationale: Myocardial infarction (MI) is a severe global clinical condition with widespread
prevalence. The adult mammalian heart's limited capacity to generate new cardiomyocytes …

Hyperactivation of ribosome biogenesis (RiBi) drives cancer progression, yet the role of RiBi-
associated proteins (RiBPs) in breast cancer (BC) is underexplored. In this study, we …

Cancer cells often experience nutrient-limiting conditions because of their robust
proliferation and inadequate tumour vasculature, which results in metabolic adaptation to …

The homeobox transcription factors HoxA9 and Meis1 are causally involved in the etiology
of acute myeloid leukemia. While HoxA9 alone immortalizes cells, cooperation with Meis1 is …

Koumine is an alkaloid with significant anti-anxiety, anticancer cell proliferation, and
analgesic activities, and our previous studies have shown that koumine can be used as an …

The tumor suppressor p53 and its antagonists MDM2 and MDM4 integrate stress signaling.
For instance, dysbalanced assembly of ribosomes in nucleoli induces p53. Here, we show …