Lipodystrophies have been recognized since at least the nineteenth century and, despite
their rarity, tended to attract considerable medical attention because of the severity and …

Human pluripotent stem cells (hPSCs) are increasingly used for cell-based regenerative
therapies worldwide, with embryonic and induced pluripotent stem cells as potential …

The mechanistic target of rapamycin (mTOR) is a ubiquitous serine/threonine kinase that
regulates anabolic and catabolic processes, in response to environmental inputs. The …

The key factor of genome instability during aging is transposon dysregulation. This may be
due to senile changes in the expression of lamins, which epigenetically modulate …

Аннотация Дисбаланс активации транспозонов–один из важнейших факторов
нестабильности генома при старении. Причинами этого явления могут быть …

This thesis is divided into 5 chapters. In Chapter 1, the Introduction, we summarise the
necessary background to the work described in this thesis, including a discussion of major …

Цель исследования-изучить гендерные особенности содержания иммунопозитивных
по ламинам А, В1 и В2 фибробластов в образцах кожи человека при хронологическом …

In eukaryotic cells, the term chromatin describes DNA as found in vivo, where it binds to
scaffolding and other DNA-binding proteins as well as specific short RNA sequences. DNA …