Proton MRS (1H MRS) provides noninvasive, quantitative metabolite profiles of tissue and
has been shown to aid the clinical management of several brain diseases. Although most …

The exquisite soft tissue contrast provided by magnetic resonance imaging arises principally
from differences in the intrinsic relaxation properties, T 1 and T 2. Although the intricate …

Mutations in the isocitrate dehydrogenase genes (IDH1/2) occur often in diffuse gliomas,
where they are associated with abnormal accumulation of the oncometabolite 2 …

Acidity within the extracellular milieu is a hallmark of cancer. There is a current need for fast,
high spatial resolution pH imaging techniques for clinical evaluation of cancers, including …

Purpose To estimate the accuracy of predicting response to neoadjuvant chemotherapy
(NACT) in patients with locally advanced breast cancer using MR spectroscopy (MRS) …

It is unclear whether alterations in cerebral pH underlie Alzheimer's disease (AD) and other
dementias. We performed proton spectroscopy after oral administration of histidine in …

Purpose The transverse relaxation times T2 of 17 metabolites in vivo at 3T is reported and
region specific differences are addressed. Methods An echo‐time series protocol was …

Abstract Proton (1 H) Magnetic Resonance Spectroscopy (MRS) is a non-invasive tool
capable of quantifying brain metabolite concentrations in vivo. Prioritization of …

Purpose To develop a novel method to achieve fast, high‐resolution, 3D multi‐TE 1H‐MRSI
of the brain. Methods A new multi‐TE MRSI acquisition strategy was developed that …

Purpose To evaluate the T2 relaxation time of lactate (Lac) in brain tumors and the
correlation of the T2 and concentration with tumor grades. Methods Eight pairs of the …