Perturbations in endoplasmic reticulum (ER) homeostasis, including depletion of Ca 2+ or
altered redox status, induce ER stress due to protein accumulation, misfolding and …

Type 2 diabetes mellitus (T2DM), accounting for 90–95% cases of diabetes, is characterized
by chronic inflammation. The mechanisms that control inflammation activation in T2DM are …

Although many types of ancient bacteria and archea rely on hydrogen sulfide (H2S) for their
energy production, eukaryotes generate ATP in an oxygen-dependent fashion. We …

Vascular disease was for a long time considered a disease of the old age, but it is becoming
increasingly clear that a cumulus of factors can cause early vascular aging (EVA) …

The endoplasmic reticulum (ER) is commonly referred to as the factory of the cell, as it is
responsible for a large amount of protein and lipid synthesis. As a membrane-bound …

Empagliflozin, a selective sodium-glucose co-transporter-2 inhibitor, has been demonstrated
to provide additional non-glycemic benefits, including neuroprotection. Endoplasmic …

Arsenic is the leading toxicant of hazardous environmental chemicals, which is linked with
neurotoxicity including cognitive dysfunction, neurodevelopmental alterations and …

Type 2 diabetes mellitus (T2DM) is a multifactorial non-communicable disease that is
characterized by insulin resistance and chronic sub-clinical inflammation. Among the …

Based on gestational age at diagnosis and/or delivery, pre‐eclampsia (PE) is commonly
divided into early‐onset (< 34 weeks) and late‐onset (≥ 34 weeks) forms. Recently, the …

The endoplasmic reticulum (ER) contains stress sensors which recognize the accumulation
of unfolded proteins within the lumen of ER, and subsequently these transducers stimulate …