Nitric oxide (NO) contributes to carbohydrate metabolism and decreased NO bioavailability
is involved in the development of type 2 diabetes mellitus (T2DM). NO donors may improve …

Insulin-degrading enzyme (IDE) is a highly conserved and ubiquitously expressed
metalloprotease that degrades insulin and several other intermediate-size peptides. For …

Prevalence of obesity is increasing worldwide and type 2 diabetes to date is the most
devastating complication of obesity. Decreased nitric oxide bioavailability is a feature of …

Nitric oxide (NO)-sensitive soluble guanylyl cyclase (sGC), an enzyme that catalyzes the
conversion of guanosine-5′-triphosphate (GTP) to cyclic guanosine-3′, 5 …

Nitric oxide (NO) and hydrogen sulfide (H 2 S) are two gasotransmitters that are produced in
the human body and have a key role in many of the physiological activities of the various …

Purpose Reduced bioavailability of nitric oxide (NO) is associated with pathogenesis of type
2 diabetes. Nitrite can act as a substrate for generation of systemic NO. The aim of this study …

Abstract Type 2 diabetes (T2D) and Alzheimer's disease (AD) are two age‐related amyloid
diseases that affect millions of people worldwide. Broadly supported by epidemiological …

OBJECTIVE Endogenous insulin clearance (EIC) is physiologically reduced at increasing
insulin secretion rate (ISR). Computing EIC at the prevailing ISR does not distinguish the …

Polymetabolic syndrome achieved pandemic proportions and dramatically influenced public
health systems functioning worldwide. Chronic vascular complications are the major …

Introduction. Obesity and insulin resistance are associated with alterations in nitric oxide
level and insulin secretion. Previous studies demonstrated that cinnamaldehyde (CNMA) …