[HTML][HTML] Endothelial activation and dysfunction in COVID-19: from basic mechanisms to potential therapeutic approaches

Y Jin, W Ji, H Yang, S Chen, W Zhang… - Signal transduction and …, 2020 - nature.com
On 12 March 2020, the outbreak of coronavirus disease 2019 (COVID-19) was declared a
pandemic by the World Health Organization. As of 4 August 2020, more than 18 million …

[HTML][HTML] Role of C-reactive protein at sites of inflammation and infection

NR Sproston, JJ Ashworth - Frontiers in immunology, 2018 - frontiersin.org
C-reactive protein (CRP) is an acute inflammatory protein that increases up to 1,000-fold at
sites of infection or inflammation. CRP is produced as a homopentameric protein, termed …

Effect of a single dose of the interleukin-6 receptor antagonist tocilizumab on inflammation and troponin T release in patients with non-ST-elevation myocardial …

O Kleveland, G Kunszt, M Bratlie, T Ueland… - European heart …, 2016 - academic.oup.com
Abstract Aims Interleukin-6 (IL-6) contributes to atherosclerotic plaque destabilization and is
involved in myocardial injury during ischaemia–reperfusion. Interleukin-6 is therefore a …

From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I

M Naghavi, P Libby, E Falk, SW Casscells, S Litovsky… - Circulation, 2003 - Am Heart Assoc
Atherosclerotic cardiovascular disease results in> 19 million deaths annually, and coronary
heart disease accounts for the majority of this toll. Despite major advances in treatment of …

Cardiovascular risk factors and molecular routes underlying endothelial dysfunction: Novel opportunities for primary prevention

G Benincasa, E Coscioni, C Napoli - Biochemical Pharmacology, 2022 - Elsevier
One of the major challenges of cardiovascular primary prevention approach is the absence
of early biomarkers of endothelial dysfunction which may be useful for identifying at-risk …

Mortality in COPD: role of comorbidities

DD Sin, NR Anthonisen, JB Soriano… - European Respiratory …, 2006 - Eur Respiratory Soc
Chronic obstructive pulmonary disease (COPD) represents an increasing burden throughout
the world. COPD-related mortality is probably underestimated because of the difficulties …

C-reactive protein and the risk of developing hypertension

HD Sesso, JE Buring, N Rifai, GJ Blake, JM Gaziano… - Jama, 2003 - jamanetwork.com
ContextAlthough it has been hypothesized that hypertension is in part an inflammatory
disorder, clinical data linking inflammation with incident hypertension are scarce …

Adipokines: molecular links between obesity and atheroslcerosis

DCW Lau, B Dhillon, H Yan… - American Journal of …, 2005 - journals.physiology.org
Atherosclerotic disease remains the leading cause of death in industrialized nations despite
major advances in its diagnosis, treatment, and prevention. The increasing epidemic of …

A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide production and inhibits angiogenesis

S Verma, CH Wang, SH Li, AS Dumont, PWM Fedak… - Circulation, 2002 - Am Heart Assoc
Background—Given the central importance of nitric oxide (NO) in the development and
clinical course of cardiovascular diseases, we sought to determine whether the powerful …

Inflammatory markers and incident heart failure risk in older adults: the Health ABC (Health, Aging, and Body Composition) study

A Kalogeropoulos, V Georgiopoulou, BM Psaty… - Journal of the American …, 2010 - jacc.org
Objectives: The purpose of this study was to evaluate the association between inflammation
and heart failure (HF) risk in older adults. Background: Inflammation is associated with HF …