The ultimate goal of radiation oncology is to eradicate tumours without toxicity to non-
malignant tissues. FLASH radiotherapy, or the delivery of ultra-high dose rates of radiation …

Radiotherapy is a cornerstone of both curative and palliative cancer care. However,
radiotherapy is severely limited by radiation-induced toxicities. If these toxicities could be …

Importance To our knowledge, there have been no clinical trials of ultra-high-dose-rate
radiotherapy delivered at more than 40 Gy/sec, known as FLASH therapy, nor first-in-human …

FLASH radiotherapy is the delivery of ultra-high dose rate radiation several orders of
magnitude higher than what is currently used in conventional clinical radiotherapy, and has …

Purpose: Recent data have shown that single-fraction irradiation delivered to the whole
brain in less than tenths of a second using FLASH radiotherapy (FLASH-RT), does not elicit …

The clinical translation of FLASH radiotherapy (RT) requires challenges related to dosimetry
and beam monitoring of ultra‐high dose rate (UHDR) beams to be addressed. Detectors …

Purpose Recent studies suggest that ultrahigh-dose-rate,“FLASH,” electron radiation
therapy (RT) decreases normal tissue damage while maintaining tumor response compared …

Abstract FLASH radiotherapy (FLASH-RT) is a technology that could modify the way
radiotherapy is delivered in the future. This technique involves the ultra-fast delivery of …

Background When compared to conventional radiotherapy (RT) in pre-clinical studies,
FLASH-RT was shown to reproducibly spare normal tissues, while preserving the anti-tumor …

Here, we highlight the potential translational benefits of delivering FLASH radiotherapy
using ultra-high dose rates (> 100 Gy⋅ s− 1). Compared with conventional dose-rate …