The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that
cause tuberculosis in both humans and animals. This illness, still today, remains to be one of …

In this review we discuss recent progress in the development, testing, and clinical evaluation
of new vaccines against tuberculosis (TB). Over the last 20 years, tremendous progress has …

Molecular typing has revolutionized epidemiological studies of infectious diseases,
including those of a mycobacterial etiology. With the advent of fingerprinting techniques …

Although the bovine tuberculosis (TB) agent, Mycobacterium bovis, may infect humans and
cause disease, long-term epidemiological data indicate that humans represent a spill-over …

Mycobacterium tuberculosis is a prototrophic, metabolically flexible bacterium that has
achieved a spread in the human population that is unmatched by any other bacterial …

Tuberculosis (TB) remains the second most common cause of death due to a single
infectious agent. The cell envelope of Mycobacterium tuberculosis (Mtb), the causative agent …

Inactivation of the transcriptional regulator PhoP results in Mycobacterium tuberculosis
attenuation. Preclinical testing has shown that attenuated M. tuberculosis phoP mutants hold …

The ESX-1 system is responsible for the secretion of the prototypic ESX proteins, namely the
6kDa early secreted antigenic target (ESAT-6) and the 10kDa culture filtrate protein (CFP …

The capacity of infected cells to undergo apoptosis upon insult with a pathogen is an ancient
innate immune defense mechanism. Consequently, the ability of persisting, intracellular …

The PhoPR two-component system is essential for virulence in Mycobacterium tuberculosis
where it controls expression of approximately 2% of the genes, including those for the ESX-1 …