Sialic acids as receptors for pathogens

P Burzyńska, ŁF Sobala, K Mikołajczyk, M Jodłowska… - Biomolecules, 2021 - mdpi.com
Carbohydrates have long been known to mediate intracellular interactions, whether within
one organism or between different organisms. Sialic acids (Sias) are carbohydrates that …

“Omics” Technologies - What Have They Told Us About Uropathogenic Escherichia coli Fitness and Virulence During Urinary Tract Infection?

S Torres-Puig, V García, K Stærk… - Frontiers in cellular …, 2022 - frontiersin.org
Uropathogenic Escherichia coli (UPEC) is the main etiological agent of urinary tract infection
(UTI), a widespread infectious disease of great impact on human health. This is further …

A previously uncharacterized two-component signaling system in uropathogenic Escherichia coli coordinates protection against host-derived oxidative stress with …

H Gu, X Cai, X Zhang, J Luo, X Zhang, X Hu… - PLoS …, 2021 - journals.plos.org
Uropathogenic Escherichia coli (UPEC) deploy an array of virulence factors to successfully
establish urinary tract infections. Hemolysin is a pore-forming toxin, and its expression …

Ucl fimbriae regulation and glycan receptor specificity contribute to gut colonisation by extra-intestinal pathogenic Escherichia coli

SJ Hancock, AW Lo, T Ve, CJ Day, L Tan… - PLoS …, 2022 - journals.plos.org
Extra-intestinal pathogenic Escherichia coli (ExPEC) belong to a critical priority group of
antibiotic resistant pathogens. ExPEC establish gut reservoirs that seed infection of the …

Progress toward a vaccine for extraintestinal pathogenic E. coli (ExPEC) II: efficacy of a toxin-autotransporter dual antigen approach

Y Xing, JR Clark, JD Chang, JJ Zulk… - Infection and …, 2024 - Am Soc Microbiol
ABSTRACT Extraintestinal pathogenic Escherichia coli (ExPEC) is a leading cause of
worldwide morbidity and mortality, the top cause of antimicrobial-resistant (AMR) infections …

RfaH Counter-Silences Inhibition of Transcript Elongation by H-NS–StpA Nucleoprotein Filaments in Pathogenic Escherichia coli

CM Hustmyer, MB Wolfe, RA Welch, R Landick - Mbio, 2022 - Am Soc Microbiol
Expression of virulence genes in pathogenic Escherichia coli is controlled in part by the
transcription silencer H-NS and its paralogs (eg, StpA), which sequester DNA in multi-kb …

Genetic basis of I-complex plasmid stability and conjugation

ZJ Lian, MD Phan, SJ Hancock, NTK Nhu… - Plos …, 2023 - journals.plos.org
Plasmids are major drivers of increasing antibiotic resistance, necessitating an urgent need
to understand their biology. Here we describe a detailed dissection of the molecular …

[HTML][HTML] Hemolysin from Aeromonas hydrophila enhances the host's serum enzyme activity and regulates transcriptional responses in the spleen of Cyprinus …

M Li, D Li, F Li, W Liu, S Wang, G Wu, G Wu… - Ecotoxicology and …, 2023 - Elsevier
Aeromonas hydrophila is a conditional pathogen impacting public hygiene and safety.
Hemolysin is a virulence factor of Aeromonas hydrophila that causes erythrocyte hemolysis …

Characteristics of Virulence Factors and Prevalence of Virulence Markers in Resistant Escherichia coli from Patients with Gut and Urinary Infections in Lafia, Nigeria

OO Orole, SM Gambo, VS Fadayomi - Microbiology insights, 2022 - journals.sagepub.com
The spread and transfer of resistant pathogens is on the increase worldwide and it is
presently a cause of concern for health facilities, health organizations and governments …

Genome placement of alpha-haemolysin cluster is associated with alpha-haemolysin sequence variation, adhesin and iron acquisition factor profile of Escherichia coli

R Kolenda, K Sidorczuk, M Noszka… - Microbial …, 2021 - microbiologyresearch.org
Since the discovery of haemolysis, many studies focused on a deeper understanding of this
phenotype in Escherichia coli and its association with other virulence genes, diseases and …