Cellular membranes function as permeability barriers that separate cells from the external
environment or partition cells into distinct compartments. These membranes are lipid …

ABCA4 is a member of the superfamily of ATP-binding cassette (ABC) transporters that is
preferentially localized along the rim region of rod and cone photoreceptor outer segment …

ATP11C, a plasma membrane phospholipid flippase, maintains the asymmetric distribution
of phosphatidylserine accumulated in the inner leaflet. Caspase-dependent inactivation of …

ABCA4 is an ATP-binding cassette (ABC) transporter that flips N-retinylidene-
phosphatidylethanolamine (N-Ret-PE) from the lumen to the cytoplasmic leaflet of …

Xkr8–Basigin is a plasma membrane phospholipid scramblase activated by kinases or
caspases. We combined cryo-EM and X-ray crystallography to investigate its structure at an …

P4-ATPases, a subfamily of P-type ATPases, translocate cell membrane phospholipids from
the exoplasmic/luminal leaflet to the cytoplasmic leaflet to generate and maintain membrane …

ATP11A translocates phosphatidylserine (PtdSer), but not phosphatidylcholine (PtdCho),
from the outer to the inner leaflet of plasma membranes, thereby maintaining the asymmetric …

In human cells, P5B-ATPases execute the active export of physiologically important
polyamines such as spermine from lysosomes to the cytosol, a function linked to a palette of …

The P4 ATPases use ATP hydrolysis to transport large lipid substrates across lipid bilayers.
The structures of the endosome-and Golgi-localized phosphatidylserine flippases—such as …

The cytoplasmic polyamine maintains cellular homeostasis by chelating toxic metal cations,
regulating transcriptional activity, and protecting DNA. ATP13A2 was identified as a …