Mesenchymal stromal/stem cells in regenerative medicine and tissue engineering

REB Fitzsimmons, MS Mazurek, A Soos… - Stem cells …, 2018 - Wiley Online Library
As a result of over five decades of investigation, mesenchymal stromal/stem cells (MSCs)
have emerged as a versatile and frequently utilized cell source in the fields of regenerative …

Five decades later, are mesenchymal stem cells still relevant?

M Gomez-Salazar, ZN Gonzalez-Galofre… - … in bioengineering and …, 2020 - frontiersin.org
Mesenchymal stem cells are culture-derived mesodermal progenitors isolatable from all
vascularized tissues. In spite of multiple fundamental, pre-clinical and clinical studies, the …

Human perivascular stem cell-derived extracellular vesicles mediate bone repair

J Xu, Y Wang, CY Hsu, Y Gao, CA Meyers, L Chang… - Elife, 2019 - elifesciences.org
The vascular wall is a source of progenitor cells that are able to induce skeletal repair,
primarily by paracrine mechanisms. Here, the paracrine role of extracellular vesicles (EVs) …

In-vitro characterization of canine multipotent stromal cells isolated from synovium, bone marrow, and adipose tissue: a donor-matched comparative study

RN Bearden, SS Huggins, KJ Cummings… - Stem cell research & …, 2017 - Springer
Background The dog represents an excellent large animal model for translational cell-based
studies. Importantly, the properties of canine multipotent stromal cells (cMSCs) and the ideal …

Pericytes as a source of osteogenic cells in bone fracture healing

S Supakul, K Yao, H Ochi, T Shimada… - International journal of …, 2019 - mdpi.com
Pericytes are mesenchymal cells that surround the endothelial cells of small vessels in
various organs. These cells express several markers, such as NG2, CD146, and PDGFRβ …

Cell encapsulation in alginate-based microgels using droplet microfluidics; a review on gelation methods and applications

M Mohajeri, M Eskandari, ZS Ghazali… - Biomedical Physics & …, 2022 - iopscience.iop.org
Cell encapsulation within the microspheres using a semi-permeable polymer allows the two-
way transfer of molecules such as oxygen, nutrients, and growth factors. The main …

The influence of inflammation on the characteristics of adipose-derived mesenchymal stem cells (ADMSCs) and tissue repair capability in a hepatic injury mouse …

J Xiao, X Gong, Z Fu, X Song, Q Ma, J Miao… - Stem Cell Research & …, 2023 - Springer
Abstract Background Mesenchymal stem cells (MSCs) are adult stem cells with self-renewal
and multi-directional differentiation potential and possess the functions of …

Allogenic use of human placenta-derived stromal cells as a highly active subtype of mesenchymal stromal cells for cell-based therapies

R Gorodetsky, WK Aicher - International journal of molecular sciences, 2021 - mdpi.com
The application of mesenchymal stromal cells (MSCs) from different sources, including bone
marrow (BM, bmMSCs), adipose tissue (atMSCs), and human term placenta (hPSCs) has …

Perivascular mesenchymal progenitors for bone regeneration

AW James, B Péault - Journal of Orthopaedic Research®, 2019 - Wiley Online Library
Mesenchymal progenitor cells reside in all assayed vascularized tissues, and are broadly
conceptualized to participate in homeostasis/renewal and repair. The application of …

The Therapeutic Potential of Pericytes in Bone Tissue Regeneration

A Issabekova, G Kudaibergen, A Sekenova, A Dairov… - Biomedicines, 2023 - mdpi.com
Pericytes, as perivascular cells, are present in all vascularized organs and tissues, and they
actively interact with endothelial cells in capillaries and microvessels. Their involvement …