[HTML][HTML] High fat diet, gut microbiome and gastrointestinal cancer

Y Tong, H Gao, Q Qi, X Liu, J Li, J Gao, P Li, Y Wang… - Theranostics, 2021 - ncbi.nlm.nih.gov
Gastrointestinal cancer is currently one of the main causes of cancer death, with a large
number of cases and a wide range of lesioned sites. A high fat diet, as a public health …

Mild suppression of hyperinsulinemia to treat obesity and insulin resistance

MM Page, JD Johnson - Trends in Endocrinology & Metabolism, 2018 - cell.com
Insulin plays roles in lipid uptake, lipolysis, and lipogenesis, in addition to controlling blood
glucose levels. Excessive circulating insulin is associated with adipose tissue expansion …

Hyperinsulinemia acts via acinar insulin receptors to initiate pancreatic cancer by increasing digestive enzyme production and inflammation

AMY Zhang, YH Xia, JSH Lin, KH Chu, WCK Wang… - Cell Metabolism, 2023 - cell.com
The rising pancreatic cancer incidence due to obesity and type 2 diabetes is closely tied to
hyperinsulinemia, an independent cancer risk factor. Previous studies demonstrated …

Defining a metabolic landscape of tumours: genome meets metabolism

C Seth Nanda, SV Venkateswaran, N Patani… - British journal of …, 2020 - nature.com
Cancer is a complex disease of multiple alterations occuring at the epigenomic, genomic,
transcriptomic, proteomic and/or metabolic levels. The contribution of genetic mutations in …

Environmental risk factors for pancreatic cancer: an update

E Barone, A Corrado, F Gemignani, S Landi - Archives of Toxicology, 2016 - Springer
Pancreatic cancer (PC) is one of the most aggressive diseases. Only 10% of all PC cases
are thought to be due to genetic factors. Here, we analyzed the most recently published case …

Glycemic status, insulin resistance, and risk of pancreatic cancer mortality in individuals with and without diabetes

NH Kim, Y Chang, SR Lee, S Ryu… - Official journal of the …, 2020 - journals.lww.com
METHODS: This is a cohort study of 572,021 Korean adults without cancer at baseline, who
participated in repeat screening examinations which included fasting blood glucose …

Pancreatic cancer and diabetes mellitus

A Sharma, ST Chari - Current treatment options in gastroenterology, 2018 - Springer
Purpose of review The relationship between pancreatic ductal adenocarcinoma (PDAC) and
diabetes mellitus (DM) is complex. We reviewed the recent medical literature regarding the …

Endogenous hyperinsulinemia contributes to pancreatic cancer development

AMY Zhang, J Magrill, TJJ de Winter, X Hu, S Skovsø… - Cell metabolism, 2019 - cell.com
The incidence of cancers, including pancreatic ductal adenocarcinoma (PDAC), continues to
rise alongside the global obesity and diabetes epidemics. This rise suggests that factors …

Targeting adipokines in obesity-related tumors

X Pu, D Chen - Frontiers in Oncology, 2021 - frontiersin.org
Obesity, a global epidemic, is an independent risk factor for the occurrence and
development of a variety of tumors, such as breast cancer, pancreatic cancer, ovarian …

[HTML][HTML] Perioperative and survival outcomes following neoadjuvant FOLFIRINOX versus gemcitabine abraxane in patients with pancreatic adenocarcinoma

BC Chapman, A Gleisner, D Rigg… - JOP: Journal of the …, 2018 - ncbi.nlm.nih.gov
Perioperative and Survival Outcomes Following Neoadjuvant FOLFIRINOX versus
Gemcitabine Abraxane in Patients with Pancreatic Adenocarcinoma - PMC Back to Top …