The African continent is poised to have a pivotal role in the global population landscape,
with the United Nations projecting a population of 2.5 billion (more than 25% of the global …

The genetic etiology of non-syndromic hearing impairment (NSHI) is highly heterogeneous
with over 124 distinct genes identified. The wide spectrum of implicated genes has …

Myosin-19 (Myo19) controls the size, morphology, and distribution of mitochondria, but the
underlying role of Myo19 motor activity is unknown. Complicating mechanistic in vitro …

The rich and diverse genomics of African populations is significantly underrepresented in
reference and in disease-associated databases. This renders interpreting the Next …

Endogenous glucocorticoids (GC) are known to modulate basic elements of cochlear
physiology. These include both noise-induced injury and circadian rhythms. While GC …

Hearing impairment (HI) is the most common neurosensory disorder globally and is reported
to be more prevalent in low-income countries. In high-income countries, up to 50% of …

Background: Hearing loss (HL) is the most common disorder in newborns with a highly
heterogeneous genetic background. Despite significant progress in screening and …

Hearing loss (HL) is the most common sensory disorder worldwide and arises from a
heterogeneous set of genetic and environmental etiologies. Currently, therapy for …

Leroy Hood and Nathan Price argue with passion, excellence, and personal experience for
a proactive approach to achieving the real potential of precision health, developed around …

We recently showed that variants in GJB2 explained Hearing Impairment (HI) in 34.1%(n=
15/44) of multiplex families in Senegal. The present study aimed to use community-based …