The increasing use of antibiotics in animal production has become an emergent
environmental problem. The large percentages of applied antibiotic doses eliminated in …

Mitochondrial diseases (MDs) are a heterogeneous group of disorders resulting from
mutations in nuclear or mitochondrial DNA genes encoding mitochondrial proteins,. MDs …

T cells orchestrate adaptive and innate immune responses against pathogens and
transformed cells. However, T cells are also the main adaptive effector cells that mediate …

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, is one of the oldest
and most successful pathogens in the world. Diverse selective pressures encountered within …

Moderate mitochondrial stress can lead to persistent activation of cytoprotective
mechanisms–a phenomenon termed mitohormesis. Here, we show that mitohormesis …

Antimicrobial resistance (AMR) is a major global health concern, further complicated by its
spread via the microbiome bacterial members. While mathematical models discuss AMR …

The heterogeneity of protein-rich inclusions and its significance in neurodegeneration is
poorly understood. Standard patient-derived iPSC models develop inclusions neither …

Summary Long-term potentiation (LTP), a well-characterized form of synaptic plasticity, is
believed to underlie memory formation. Hebbian, postsynaptically expressed LTP requires …

Maintaining mitochondrial function is critical to an improved healthspan and lifespan.
Introducing mild stress by inhibiting mitochondrial translation invokes the mitochondrial …

The production of recombinant proteins for functional and biophysical studies, especially in
the field of structural determination, still represents a challenge as high quality and …