Epithelial and hematopoietic cells have a high turnover and their progenitor cells divide
continuously, making them prime targets for genetic and epigenetic changes that lead to cell …

Abstract The Ras/Raf/Mitogen-activated protein kinase/ERK kinase (MEK)/extracellular-
signal-regulated kinase (ERK) cascade couples signals from cell surface receptors to …

The epigenome is defined by DNA methylation patterns and the associated posttranslational
modifications of histones. This histone code determines the expression status of individual …

TGF-β binding to the cell surface triggers activation of multiple signal transduction pathways
that are connected in intricate ways with each other, and with other response networks …

▪ Abstract Acetylation is a key posttranslational modification of many proteins responsible for
regulating critical intracellular pathways. Although histones are the most thoroughly studied …

The epidermal growth factor receptor (EGFR) is overexpressed in the majority of non–small
cell lung cancers (NSCLC). EGFR tyrosine kinase inhibitors, such as gefitinib and erlotinib …

TGF-β signaling regulates diverse cellular processes, including cell proliferation,
differentiation, apoptosis, cell plasticity and migration. Its dysfunctions can result in various …

Abstract Effects of the histone deacetylase (HDAC) inhibitor MS-275 have been examined in
human leukemia and lymphoma cells (U937, HL-60, K562, and Jurkat) as well as in primary …

The TGF-β signaling network plays a complex role in carcinogenesis because it has the
potential to act as either a tumor suppressor or a pro-oncogenic pathway. Currently, it is not …

Purpose The objective of this study was to define the maximum-tolerated dose (MTD), the
recommended phase II dose, the dose-limiting toxicity, and determine the pharmacokinetic …