Ion channels are integral membrane proteins present on the plasma membrane as well as
intracellular membranes. In the human genome, there are more than 400 known genes …

During bone resorption, the osteoclast must sustain an extraordinarily low pH environment,
withstand immense ionic pressures, and coordinate nutrient and waste exchange across its …

The Chloride Intracellular Ion Channel (CLIC) family consists of six evolutionarily conserved
proteins in humans. Members of this family are unusual, existing as both monomeric soluble …

Emerging evidences demonstrate significance of chloride channels in cardiac function and
cardioprotection from ischemia–reperfusion (IR) injury. Unlike mitochondrial potassium …

Intracellular organelles are membranous structures central for maintaining cellular
physiology and the overall health of the cell. To maintain cellular function, intracellular …

The CLIC proteins are a highly conserved family of metazoan proteins with the unusual
ability to adopt both soluble and integral membrane forms. The physiological functions of …

Ion channels represent a large class of drug targets, but their role in brain cancer is
underexplored. Here, we identify that chloride intracellular channel 1 (CLIC1) is …

Background: A membrane protein interaction with lipids shows distinct specificity in terms of
the sterol structure. The structure of the sterol's polar headgroup, steroidal rings, and …

Ovarian cancer (OC) is a disease that most often affects post-menopausal women who
present abdominal discomfort and bloating over a few months prior to detection. The …

Intracellular chloride channel protein 1 (CLIC1) participates in inflammatory processes by
regulating macrophage phagosomal functions such as pH and proteolysis. Here, we sought …