A Semi-Mechanistic Physiologically Based Biopharmaceutics Model to Describe Complex and Saturable Absorption of Metformin: Justification of Dissolution …
Physiologically based pharmacokinetic (PBPK) or physiologically based biopharmaceutics
models (PBBM) demonstrated plethora of applications in both new drugs and generic …
models (PBBM) demonstrated plethora of applications in both new drugs and generic …
More Than a Gut Feeling─ A Combination of Physiologically Driven Dissolution and Pharmacokinetic Modeling as a Tool for Understanding Human Gastric Motility
M Romański, M Staniszewska, J Dobosz… - Molecular …, 2024 - ACS Publications
In vivo studies of formulation performance with in vitro and/or in silico simulations are often
limited by significant gaps in our knowledge of the interaction between administered dosage …
limited by significant gaps in our knowledge of the interaction between administered dosage …
Integrating Clinical Variability into PBPK Models for Virtual Bioequivalence of Single and Multiple Doses of Tofacitinib Modified‐Release Dosage Form
V Purohit, K Sagawa, HJ Hsu, J Kushner… - Clinical …, 2024 - Wiley Online Library
Tofacitinib is a potent, selective inhibitor of the Janus kinase (JAK) family of kinases with a
high degree of selectivity within the human genome's set of protein kinases. Currently …
high degree of selectivity within the human genome's set of protein kinases. Currently …