Multiple drug resistance (MDR), referring to the resistance of cancer cells to a broad
spectrum of structurally and mechanistically unrelated drugs across membranes, severely …

Epilepsy is a common neurological disorder that affects over 70 million people worldwide.
Despite the recent introduction of new antiseizure drugs (ASDs), about one-third of patients …

The efficacy of chemotherapy is one of the main challenges in cancer treatment and one of
the major obstacles to overcome in achieving lasting remission and a definitive cure in …

Multidrug resistance (MDR) is a serious phenomenon employed by cancer cells which
hampers the success of cancer pharmacotherapy. One of the common mechanisms of MDR …

Kaempferol is a polyphenol antioxidant found in fruits and vegetables. Many studies have
described the beneficial effects of dietary kaempferol in reducing the risk of chronic …

Breast cancer, specifically metastatic breast, is a leading cause of morbidity and mortality in
women. This is mainly due to relapse and reoccurrence of tumor. The primary reason for …

Over the past couple of decades, antibody–drug conjugates (ADCs) have revolutionized the
field of cancer chemotherapy. Unlike conventional treatments that damage healthy tissues …

Chemoresistance is a major problem in cancer therapy as cancer cells develop mechanisms
that counteract the effect of chemotherapeutic compounds, leading to relapse and the …

Transporters influence the disposition of chemicals within the body by participating in
absorption, distribution, and elimination. Transporters of the solute carrier family (SLC) …

Resistance to conventional and target specific antitumor drugs still remains one of the major
cause of treatment failure and patience death. This condition often involves ATP-binding …