Runs of homozygosity: current knowledge and applications in livestock

E Peripolli, DP Munari, M Silva, ALF Lima… - Animal …, 2017 - Wiley Online Library
This review presents a broader approach to the implementation and study of runs of
homozygosity (ROH) in animal populations, focusing on identifying and characterizing ROH …

Inbreeding depression in livestock species: review and meta‐analysis

G Leroy - Animal genetics, 2014 - Wiley Online Library
Inbreeding, by virtue of its consequence on traits of interest, is a topic of major interest for
geneticists and animal breeders. Based on meta‐analysis conducted on 57 studies and …

Inbreeding and runs of homozygosity: A possible solution to an old problem

I Curik, M Ferenčaković, J Sölkner - Livestock science, 2014 - Elsevier
Quantifying human, plant and livestock inbreeding has been an important goal of
evolutionary biologists and agricultural scientists for nearly a century, and methods to do so …

The distribution of runs of homozygosity and selection signatures in six commercial meat sheep breeds

DC Purfield, S McParland, E Wall, DP Berry - PloS one, 2017 - journals.plos.org
Domestication and the subsequent selection of animals for either economic or
morphological features can leave a variety of imprints on the genome of a population …

Analysis of runs of homozygosity and their relationship with inbreeding in five cattle breeds farmed in Italy

G Marras, G Gaspa, S Sorbolini, C Dimauro… - Animal …, 2015 - Wiley Online Library
Increased inbreeding is an inevitable consequence of selection in livestock populations. The
analysis of high‐density single nucleotide polymorphisms (SNPs) facilitates the identification …

Inbreeding and runs of homozygosity before and after genomic selection in North American Holstein cattle

M Forutan, S Ansari Mahyari, C Baes, N Melzer… - BMC genomics, 2018 - Springer
Background While autozygosity as a consequence of selection is well understood, there is
limited information on the ability of different methods to measure true inbreeding. In the …

Estimating autozygosity from high-throughput information: effects of SNP density and genotyping errors

M Ferenčaković, J Sölkner, I Curik - Genetics Selection Evolution, 2013 - Springer
Background Runs of homozygosity are long, uninterrupted stretches of homozygous
genotypes that enable reliable estimation of levels of inbreeding (ie, autozygosity) based on …

Estimation of inbreeding using pedigree, 50k SNP chip genotypes and full sequence data in three cattle breeds

Q Zhang, MPL Calus, B Guldbrandtsen, MS Lund… - BMC genetics, 2015 - Springer
Background Levels of inbreeding in cattle populations have increased in the past due to the
use of a limited number of bulls for artificial insemination. High levels of inbreeding lead to …

Effect of artificial selection on runs of homozygosity in US Holstein cattle

ES Kim, JB Cole, H Huson, GR Wiggans… - PloS one, 2013 - journals.plos.org
The intensive selection programs for milk made possible by mass artificial insemination
increased the similarity among the genomes of North American (NA) Holsteins tremendously …

Next‐generation metrics for monitoring genetic erosion within populations of conservation concern

G Leroy, EL Carroll, MW Bruford… - Evolutionary …, 2018 - Wiley Online Library
Genetic erosion is a major threat to biodiversity because it can reduce fitness and ultimately
contribute to the extinction of populations. Here, we explore the use of quantitative metrics to …