Coronavirus disease 2019 (COVID-19) is a disease characterized by a profound
dysregulation of the innate immune system. This knowledge has emerged from the large …

Pattern recognition receptors (PRRs) and inflammasomes are a key part of the anti-viral
innate immune system as they detect conserved viral pathogen-associated molecular …

Two of the most prevalent human viruses worldwide, herpes simplex virus type 1 and type 2
(HSV-1 and HSV-2, respectively), cause a variety of diseases, including cold sores, genital …

Receptors of the innate immune system detect conserved determinants of microbial and viral
origin. Activation of these receptors initiates signaling events that culminate in an effective …

Herpes simplex virus-1 (HSV-1) establishes latency preferentially in sensory neurons of
peripheral ganglia. A variety of stresses can induce recurrent reactivations of the virus …

Toll-like receptors (TLRs) are fundamental sensor molecules of the host innate immune
system, which detect conserved molecular signatures of a wide range of microbial …

SUMMARY Herpes simplex virus 1 (HSV-1) is very successful in establishing acute and
latent infections in humans by counteracting host antiviral innate immune responses. HSV-1 …

The innate immune system constitutes the first line of defense against invading microbial
pathogens and relies on a large family of pattern recognition receptors (PRRs), which detect …

Microorganisms that invade a vertebrate host are initially recognized by the innate immune
system through germline-encoded pattern-recognition receptors (PRRs). Several classes of …

The innate immune response to viral pathogens is critical in order to mobilize protective
immunity. Cells of the innate immune system detect viral infection largely through germline …